Hep C Discussion Forum

Isiscat2011 · Isiscat2011

Harvoni scripts were ~ 4,400 for last week in the USA. Averaged out that means only ~ 88 people per state were approved (and this was the highest week yet). That doesn't seem like many from a patient's point of view. BTW, I am beginning to HATE Pharma investors. They talk about these drugs as if they we...

RudiRoo · RudiRoo

http://www.vocal-ny.org/blog/new-york-state-poised-to-deny-hepatitis-c-treatment-to-thousands/

Harvoninme · Harvoninme

Bristol-Myers Squibb Receives Complete Response Letter from U.S. Food and Drug Administration for Daclatasvir, an Investigational Treatment for Hepatitis C "Despite the recent advances in the treatment of hepatitis C there remain significant areas of unmet high need in this disease are...

Isiscat2011 · Isiscat2011

http://www.reuters.com/article/2014/11/21/us-europe-medicine-approvals-idUSKCN0J518920141121

Isiscat2011 · Isiscat2011

http://www.fiercepharma.com/story/eu-nod-sets-gileads-harvoni-record-breaking-sales/2014-11-18 "But Europe, like the U.S., has already given some indication that it may have trouble affording the drug, which checks in at $94,500 per 12-week treatment cours...

Isiscat2011 · Isiscat2011

http://blogs.wsj.com/pharmalot/2014/11/03/bristol-myers-plan-to-widen-access-to-its-hep-c-drug-but-meets-criticism/

Isiscat2011 · Isiscat2011

http://www.ajmc.com/conferences/AASLD2014/The-Real-World-Experience-With-Simprevir-and-Sofosbuvir-Based-Regimens-in-Hep-C-Treatment

Isiscat2011 · Isiscat2011

As we know the AASLD guidelines established a basis for who and when to treat. Despite the AASLD's subsequent statement that the guidelines were not intended to be used to deny tx the guidelines do in fact clearly set forth a type of rationing system. If you are wondering how docs in clinical practic...

suziq · suziq

This is a calculator that supposedly calculates the degree of fibrosis (and other things) using your standard liver blood tests. I am not sure how accurate it is. I entered my numbers and it said that I have severe fibrosis or mild cirrhosis--which is accurate. Just thought I'd share it. Is i...

Matt Chris · Matt Chris

Hey All AbbVie has been granted five US patents that specifically claim the use of Sofosbuvir and Ledipasvir, the drug combination that Gilead sales under the name of Harvoni. Check out the article Seeking alpha - http://www.seekingalpha.com/article/2674915 This will takes years of litigatio...

Fireman Rob · Fireman Rob

Okay so I'm kicking myself because I read an awesome article this morning about Gilead's new Triple (6 week regimen) and can't find it now. The nuts and bolts were that Gilead is in the early clinical stages to test Harvoni combined with another drug called "Vedroprevir" and a small sample...

Isiscat2011 · Isiscat2011

Australia's rejection of costly new treatment sofosbuvir a 'death sentence for Hepatitis C sufferers'By Deborah Cornwall Liver experts at a conference on the Gold Coast have been warned Australia is on the verge of a catastrophic death spiral from Hepatitis C. Dr Miriam Levy, the director of gas...

Lowrider · Lowrider

http://www.reuters.com/article/2014/11/10/us-merck-co-hepatitis-idUSKCN0IU00K20141110?feedType=RSS&feedName=healthNews

Isiscat2011 · Isiscat2011

http://hepatitiscnewdrugresearch.com/2014-hepatitis-c---breaking-conference-reports.html-- Edit...

Isiscat2011 · Isiscat2011

On May 7, 2014 the manufacturer of Olysio (Janssen) submitted a supplemental new drug application to use Olysio in combination with Sovaldi. Up until now the use of S/O has been off-label. I just got an email update from the FDA that indicates the FDA has approved the S/O combo. It states in pertinen...

Isiscat2011 · Isiscat2011

A recent article written by a doctor that is well worth the read: Delivering on the Promise: Maximizing SVR in the Real WorldJordan J. Feld, MD, MPH - 10/6/2014 More from this authorWith the promise of curing up to 75% of patients infected with genotype 1 HCV, the approval of the first-generatio...

Isiscat2011 · Isiscat2011

The CEO of PBM Express Scripts has been very outspoken about Gilead's pricing. In the news (and on his blog) he is saying that Express Scripts may drop Harvoni from its formulary once Abbvie is approved assuming Abbvie is more reasonably priced. It appears the Insurance Cos and PBMs are sending a me...

Brownie · Brownie

This is OLYSIO !Sunday, October 26, 2014Posted by HCV New DrugsFILE UNDERHCV NEWS, HCV WORLDWIDE,SIDE EFFECTS,SIMEPREVIR3 die after being administered hepatitis C drug The health ministry said Friday three people have died after taking the hepatitis C drug Sovriad, and it has ordered the dis...

Huey · Huey

http://blogs.hepmag.com/lucindakporter/2014/10/harvoni_what_you_nee.html

LC · LC

http://www.marketwired.com/press-release/move-over-gilead-abbvie-could-bring-serious-competition-to-hcv-market-1956910.htm

OldenSlow · OldenSlow

"While Gilead has contended that the total price for a course of treatment with a Sovaldi-containing regimen was a modest increase compared with previous standards of care, this is an invalid argument based on the incorrect premise that these regimens were appropriately priced to begin wit...

Huey · Huey

http://au.ibtimes.com/articles/569239/20141011/biotron-limited-asx-bit-hiv-cure-hepatitis.htm#.VDlTmSWP-EU

Isiscat2011 · Isiscat2011

Following FDA approval today of Harvoni, Gilead's newest--and first all-oral--treatment for hepatitis C, AHF and other drug pricing advocates, blasted the Bay Area drug maker for the $94,500 price for the drug, $125 above the $1,000 per pill Gilead currently charges for its current Sovaldi form...

Isiscat2011 · Isiscat2011

More states have enacted restrictions on Medicaid coverage of Sovaldi. The count is now up to 70% of states and can be expected to increase. Below is a state-by-state overview of those that have restrictions to limit the tx to the sickest. Expect to see similar prior authorization requirements fr...

Isiscat2011 · Isiscat2011

BMS has withdrawn its NDA for asunaprevir. As you may recall the BMS combo of asunaprevir/declatasvir was scheduled for approval in December. BMS does intend to pursue the approval of declatasvir alone, however. This is actually good news because Declatasvir has been used in combination with...

Huey · Huey

http://blogs.scientificamerican.com/absolutely-maybe/2014/10/10/the-hepatitis-c-escalation-baby-boomer-ripple-effects/

Isiscat2011 · Isiscat2011

The French are not happy about Gilead's pricing and they intend to do something about it. "The government will selectively tax drugmakers when the total cost to the state from their hepatitis C drugs exceeds a certain amount each year, " http://hepatitiscnewdrugs.blogspot.com/20...

Huey · Huey

http://medicalxpress.com/news/2014-10-real-dynamic-motion-hiv-readies.html

Tig · Tig

Great news for our Japanese members! "Bristol-Myers Squibb announced in July that the Japanese Ministry of Health, Labor and Welfare approved daclatasvir, a potent, pan-genotypic NS5A replication complex inhibitor, and asunaprevir, an NS3/4A protease inhibitor, for patients with hep...

Tig · Tig

Abbvie has in tandem with their latest television advertising program, developed/sponsored a new patient assistance website. It's designed to help people understand and provide individual help on treatment possibilities. I thought those that have missed it or haven't seen the on air and onlin...

Topic		Started By	Replies	Views	Last Post
	Harvoni Scripts (Preview) Harvoni scripts were ~ 4,400 for last week in the USA. Averaged out that means only ~ 88 people per state were approved (and this was the highest week yet). That doesn't seem like many from a patient's point of view. BTW, I am beginning to HATE Pharma investors. They talk about these drugs as if they we...	Isiscat2011	8	1780	Dec 1, 2014 by B161
	NY State poised to deny Hep C TX (Preview) http://www.vocal-ny.org/blog/new-york-state-poised-to-deny-hepatitis-c-treatment-to-thousands/	RudiRoo	8	1337	Nov 30, 2014 by Groupergetter
	Daclatasvir Delayed (Preview) Bristol-Myers Squibb Receives Complete Response Letter from U.S. Food and Drug Administration for Daclatasvir, an Investigational Treatment for Hepatitis C "Despite the recent advances in the treatment of hepatitis C there remain significant areas of unmet high need in this disease are...	Harvoninme	0	657	Nov 28, 2014 by Harvoninme
	ABBVie & Europe (Preview) http://www.reuters.com/article/2014/11/21/us-europe-medicine-approvals-idUSKCN0J518920141121	Isiscat2011	1	906	Nov 21, 2014 by Matt Chris
	Harvoni Gets European Marketing Approval (Preview) http://www.fiercepharma.com/story/eu-nod-sets-gileads-harvoni-record-breaking-sales/2014-11-18 "But Europe, like the U.S., has already given some indication that it may have trouble affording the drug, which checks in at $94,500 per 12-week treatment cours...	Isiscat2011	0	823	Nov 19, 2014 by Isiscat2011
	BMS Schemes to Exclude Mid-Income Countries (Preview) http://blogs.wsj.com/pharmalot/2014/11/03/bristol-myers-plan-to-widen-access-to-its-hep-c-drug-but-meets-criticism/	Isiscat2011	1	877	Nov 16, 2014 by Tig
	Real World S/O Results (Preview) http://www.ajmc.com/conferences/AASLD2014/The-Real-World-Experience-With-Simprevir-and-Sofosbuvir-Based-Regimens-in-Hep-C-Treatment	Isiscat2011	17	2206	Nov 14, 2014 by Isiscat2011
	How Docs Are Applying Guidelines (Preview) As we know the AASLD guidelines established a basis for who and when to treat. Despite the AASLD's subsequent statement that the guidelines were not intended to be used to deny tx the guidelines do in fact clearly set forth a type of rationing system. If you are wondering how docs in clinical practic...	Isiscat2011	0	740	Nov 14, 2014 by Isiscat2011
	Fibrosis Calculator (Preview) This is a calculator that supposedly calculates the degree of fibrosis (and other things) using your standard liver blood tests. I am not sure how accurate it is. I entered my numbers and it said that I have severe fibrosis or mild cirrhosis--which is accurate. Just thought I'd share it. Is i...	suziq	6	1511	Nov 13, 2014 by Michaele
	Gilead Sciences Gets Ambushed By The Patent Troll, AbbVie $ (Preview) Hey All AbbVie has been granted five US patents that specifically claim the use of Sofosbuvir and Ledipasvir, the drug combination that Gilead sales under the name of Harvoni. Check out the article Seeking alpha - http://www.seekingalpha.com/article/2674915 This will takes years of litigatio...	Matt Chris	6	1293	Nov 13, 2014 by LC
	Gilead's New Triple? (Preview) Okay so I'm kicking myself because I read an awesome article this morning about Gilead's new Triple (6 week regimen) and can't find it now. The nuts and bolts were that Gilead is in the early clinical stages to test Harvoni combined with another drug called "Vedroprevir" and a small sample...	Fireman Rob	1	753	Nov 11, 2014 by Gracie
	Some Perspective for Americans (Preview) Australia's rejection of costly new treatment sofosbuvir a 'death sentence for Hepatitis C sufferers'By Deborah Cornwall Liver experts at a conference on the Gold Coast have been warned Australia is on the verge of a catastrophic death spiral from Hepatitis C. Dr Miriam Levy, the director of gas...	Isiscat2011	2	861	Nov 11, 2014 by Matt Chris
	Merk four-week Hep C regimen with Sovaldi comes up short. (Preview) http://www.reuters.com/article/2014/11/10/us-merck-co-hepatitis-idUSKCN0IU00K20141110?feedType=RSS&feedName=healthNews	Lowrider	2	615	Nov 10, 2014 by LC
	New Info on HCV (Preview) http://hepatitiscnewdrugresearch.com/2014-hepatitis-c---breaking-conference-reports.html-- Edit...	Isiscat2011	2	669	Nov 10, 2014 by Zlikster
	Olysio with Sovaldi: FDA approved (Preview) On May 7, 2014 the manufacturer of Olysio (Janssen) submitted a supplemental new drug application to use Olysio in combination with Sovaldi. Up until now the use of S/O has been off-label. I just got an email update from the FDA that indicates the FDA has approved the S/O combo. It states in pertinen...	Isiscat2011	5	1158	Nov 5, 2014 by Isiscat2011
	Maximizing SVR in the Real World (Preview) A recent article written by a doctor that is well worth the read: Delivering on the Promise: Maximizing SVR in the Real WorldJordan J. Feld, MD, MPH - 10/6/2014 More from this authorWith the promise of curing up to 75% of patients infected with genotype 1 HCV, the approval of the first-generatio...	Isiscat2011	1	1024	Nov 4, 2014 by lilbit
	PBMs Showdown w/Gilead (Preview) The CEO of PBM Express Scripts has been very outspoken about Gilead's pricing. In the news (and on his blog) he is saying that Express Scripts may drop Harvoni from its formulary once Abbvie is approved assuming Abbvie is more reasonably priced. It appears the Insurance Cos and PBMs are sending a me...	Isiscat2011	5	1290	Oct 31, 2014 by Gator Man
	3 Die After Being Administered Sovriad (simeprevir sodium) Hepatitus C Drug (Preview) This is OLYSIO !Sunday, October 26, 2014Posted by HCV New DrugsFILE UNDERHCV NEWS, HCV WORLDWIDE,SIDE EFFECTS,SIMEPREVIR3 die after being administered hepatitis C drug The health ministry said Friday three people have died after taking the hepatitis C drug Sovriad, and it has ordered the dis...	Brownie	3	1213	Oct 29, 2014 by Isiscat2011
	Harvoni is ok for some pregnet women!! wow. (Preview) http://blogs.hepmag.com/lucindakporter/2014/10/harvoni_what_you_nee.html	Huey	0	884	Oct 14, 2014 by Huey
	Charts linked in article comparing the current HCV meds (Preview) http://www.marketwired.com/press-release/move-over-gilead-abbvie-could-bring-serious-competition-to-hcv-market-1956910.htm	LC	2	761	Oct 14, 2014 by LC
	Fair Pricing Coalition Urges Uniform Price for Curative Treatent (Preview) "While Gilead has contended that the total price for a course of treatment with a Sovaldi-containing regimen was a modest increase compared with previous standards of care, this is an invalid argument based on the incorrect premise that these regimens were appropriately priced to begin wit...	OldenSlow	0	676	Oct 13, 2014 by OldenSlow
	hiv-hcv co-infection cure!!! (Preview) http://au.ibtimes.com/articles/569239/20141011/biotron-limited-asx-bit-hiv-cure-hepatitis.htm#.VDlTmSWP-EU	Huey	0	752	Oct 11, 2014 by Huey
	$94.5 K (Preview) Following FDA approval today of Harvoni, Gilead's newest--and first all-oral--treatment for hepatitis C, AHF and other drug pricing advocates, blasted the Bay Area drug maker for the $94,500 price for the drug, $125 above the $1,000 per pill Gilead currently charges for its current Sovaldi form...	Isiscat2011	14	1669	Oct 10, 2014 by Isiscat2011
	Medicaid Restrictions on Sovaldi (Preview) More states have enacted restrictions on Medicaid coverage of Sovaldi. The count is now up to 70% of states and can be expected to increase. Below is a state-by-state overview of those that have restrictions to limit the tx to the sickest. Expect to see similar prior authorization requirements fr...	Isiscat2011	3	662	Oct 10, 2014 by lilbit
	BMS Withdraws New Drug Application for Asunaprevir (Preview) BMS has withdrawn its NDA for asunaprevir. As you may recall the BMS combo of asunaprevir/declatasvir was scheduled for approval in December. BMS does intend to pursue the approval of declatasvir alone, however. This is actually good news because Declatasvir has been used in combination with...	Isiscat2011	1	671	Oct 10, 2014 by Isiscat2011
	JUST OUT ! (Preview) http://blogs.scientificamerican.com/absolutely-maybe/2014/10/10/the-hepatitis-c-escalation-baby-boomer-ripple-effects/	Huey	0	590	Oct 10, 2014 by Huey
	Let Them Eat Cake (Preview) The French are not happy about Gilead's pricing and they intend to do something about it. "The government will selectively tax drugmakers when the total cost to the state from their hepatitis C drugs exceeds a certain amount each year, " http://hepatitiscnewdrugs.blogspot.com/20...	Isiscat2011	0	599	Oct 9, 2014 by Isiscat2011
	Hiv Dance (Preview) http://medicalxpress.com/news/2014-10-real-dynamic-motion-hiv-readies.html	Huey	0	628	Oct 8, 2014 by Huey
	First all oral treatment for Japan (Preview) Great news for our Japanese members! "Bristol-Myers Squibb announced in July that the Japanese Ministry of Health, Labor and Welfare approved daclatasvir, a potent, pan-genotypic NS5A replication complex inhibitor, and asunaprevir, an NS3/4A protease inhibitor, for patients with hep...	Tig	0	783	Oct 6, 2014 by Tig
	New Abbvie Patient Assistance Hep C Website (Preview) Abbvie has in tandem with their latest television advertising program, developed/sponsored a new patient assistance website. It's designed to help people understand and provide individual help on treatment possibilities. I thought those that have missed it or haven't seen the on air and onlin...	Tig	2	1437	Sep 30, 2014 by Isiscat2011
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