And another question which is imporant to me: can the virus MUTATE because of treatment the way that it can be something new unable to be cleared by any drgus?
mcmaklin said
Sep 14, 2016
Just to remind you - I have probably no NS3 RAVs - I have NS5A RAVs L31M and Q54h and genotype 1b.
My consultant believes the best available regimen here will be ABT-530 and ABT-493 which works probably the best for L31M. I trust my consultant although this is interesting what I can get to know here. ABC-530 is probably much better than Velpatasvir here
So if you want to help me just let us discuss this
Do you know anyone with genotype 1b who failed Viekira Exviera?
Canuck said
Sep 14, 2016
Pablo,
Yes, not only does this article (kind of) touch on mcmaklin's query, but so do other studies/articles stuffed inside and throughout that GT3's and sof/vel trials thread. As well, there are other articles regarding IL28b CC, CT and TT, and other articles related to RAV's (in one way or another) scattered in different threads all over this site, that are of general subject matter interest, none that outright answer what is the best regime for mcmaklin.
In quest of thee "specific" best "rescue regime" for mcmaklin, it is hard to know with any authority, the subject is so complex. Maybe Tig or malcolm can wing it with some thinking on this.
The article we have here, unfortunately, is absent of and does not highlight NS3/4A VOX (used in conjunction with sof/vel as Gilead's rescue regime) - there are other articles (mostly pro-Gilead) that speak further on this triplet rescue regime that we have yet to see to come to market.
Generally, VEL is proving itself very pan/effective regardless of GT's, CT's/TT's, RAVs, cirrhosis, etc., boasting a host of qualities that allows it to help many people better.
The next good question is (getting ahead of ourselves), if you fail sof/vel, then where do you go? But all the while you have to note that most are NOT failing sof/vel as a treatment-naļve or as a rescue regime, nor are they failing sof/vel/vox as a rescue regime.
Pablito said
Sep 14, 2016
I attach a paper on RAVs. I think I may have got it from Canuck.
Hello I am waiting for trials for those who relapsed with ABt-530
Please let me know about RAVS - I know I have L31M - what do you say sometimes "to test RAVs" in "position" 1, 2, 3. What does it mean? I know I can test for specific RAVs in Region Ns5A like L31M or Y93h. Can I test more somewhere?
do you know anyone else who relapsed after Viekira/Exviera with genotype 1b?
-- Edited by mcmaklin on Wednesday 14th of September 2016 02:01:15 PM
mcmaklin said
Sep 14, 2016
Hello - I am waiting for trials for those who relapsed - trials with
Canuck said
Aug 26, 2016
Canuck wrote:
Hi mcmaklin,
Don't know what country you are in. Here in Canada, Epclusa seems to have finished trials, but the sof/vel (perhaps with the VOX) I just did, would seem to fit your bill, as far as TT, RAVS.
They are starting to dole it out, spotty, "approved and on the market" (here and there) in U.S. One customer on site hails from Alabama, another in Ohio.
In Canada they have "technically approved" Epclusa, doing GT 1-6, 12 weeks, cirrhotics add riba. (But this does not mean anyone, anytime soon, in Canada is going to get it!) C.
I tried to edit this old post, I thought I already done so?, but it didn't work, too old I guess - this was in regard to mcmaklin (about sof/vel, etc.) - to his query about Abby drugs. I've corrected my post now (shown above) - it was OHIO not Ontario.
mcmaklin said
Aug 25, 2016
HR, How are you doing on the newest Abbvie trial? I failed Viekira+Exviera and maybe will be taking part in the 3rd phase of Abbvie Trial that you are taking? How are you? Which group are you in and how do you feel?
Canuck said
Aug 19, 2016
Hi,
Don't know what country you are in. Here in Canada, Epclusa seems to have finished trials, but the sof/vel (perhaps with the VOX) I just did, would seem to fit your bill, as far as TT, RAVS.
They are starting to dole it out, spotty, technically it is "approved and on the market" (here and there) U.S. and Canada. One customer on site hails from Alabama, another in Ohio. Canada they have "approved" doing GT 1-6, 12 weeks, cirrhotics add riba. C.
Corrected!
-- Edited by Tig56 on Saturday 27th of August 2016 03:26:17 PM
Loopy Lisa said
Aug 19, 2016
Hey folk,
Sorry to hear about the RAV's. I think these trials look promising and it gives more options for people. A choice between pills for 12 weeks and a single injection, I'd take the latter any day of the week.
I hope this time you get a cure, nothing worse than disappointment when everyone else seems to be curing...
Good luck!!!!
mcmaklin said
Aug 18, 2016
I replased a month after EOT.
What are options for me now? My consultant says that we know we are waiting for, that the most promising option among patients with NS5A mutations seems to be ABT-530 and ABT-493. That the results of researches show that they work better then other drugs against mutations.
Have you Heard about trials for those who relapsed?
Do you know other who relapsed after Viekira+Exviera?
Genotype 1b, TT, now F1, Relapsed a month after EOT after Viekira+Exviera no Riba 12 weeks in December 2015
As now is 6 months after EOT I know I have RAVs: In Region NS5A I HAVE L31M and Q54h, I do not have Y93H. I have no RAVS in regions NS3.
-- Edited by mcmaklin on Thursday 18th of August 2016 11:42:56 PM
HR said
May 10, 2015
JLynch30 wrote:
you failed harvoni 2 times? With or without Ribavirin? I have not heard of this - are there others in the same boat?
Without Ribavirin both times. I would say there are others but I don't know the number. It cures most folks the first go around so I wouldn't worry too much about my situation.
JLynch30 said
May 10, 2015
you failed harvoni 2 times? With or without Ribavirin? I have not heard of this - are there others in the same boat?
HR said
May 10, 2015
Hey Matt,
Yes. TLI is the site that called me. I have not got any info on my RAV profile since last treatment. Ive been feeling good so I haven't been really concerned about it but I think I will start to pursue that info again. They just don't like to give out that info for some reason. I asked about getting my Il28B genotype and they said Gilead has that and they ( TLI) didn't have that info. Also said that that didn't matter on these new DAA's . Well the sign up sheet for this ABBVIE trial wants you to have the IL28b test done which makes me think it might be more important than they let on.
So at any rate this ABBVIE trial is a Phase II so I'm not going to participate. I will wait for Phase 3 or something down the road a bit.
Cochrystal Pharma has some interesting things coming up. The guy from Pharmasett is there. Check out their website.
Good luck with treatment and I want to see a SVR 12 from you. Take care Buddy.
Matt Chris said
May 9, 2015
Hey HR
Nice to hear from you again, thanks for posting this info. I assume that TLI is one of the sites for this study. I had been watching these ABBvie DAA's for quite a while, reading data from NATAP it said that in vitro they had a very high barrier to HCV resistance / RAV's so it might be a good fit for either a NS5A or NS3/4 failure. BTW, HR did you get any data on your RAV's profile since your last treatment, it can be very important in choosing your next DAA selection.
matt
Tig said
May 8, 2015
Hi,
I had not seen the newest info on that, TT033 was the older article I read. After you pointed it out, I found this short article on TT034. It's an interesting protocol we're definitely going to watch! Thanks for all your info.
Its TT034 and it is an IV infusion. Single shot and you're done. As I said the 6 th patient is going to be dosed in about 6 weeks( fingers crossed no more delays) and this is where efficacy will start to show if it works. There are 5 cohorts and the 6th patient is the first in cohort 3. It's a frustrating trial to watch because of the delays but Lawitz's team has been added to the trial sites so that may help speed things up.
Yes, our friend Ribavirin is still in the mix. The lady I talked to about this Abbvie trial was saying these are second generation drugs? Anyway I just don't want to do 3 trials and it not work. I guess we will see.
Tig said
May 8, 2015
Hello,
I haven't heard much on this, but it does appear to be an effective pan genotypic combination. I don't see much discussion on treatment lengths though. I see that our old friend and enemy, Ribavirin is still in the mix. The clinical trial information states that Abbvie is sponsoring the studies on it.
Another thing I found while searching was Benitec's work with TT 033. It's a single dose regimen administered IV. I'm going to look for more current information on that.
i haven't posted in a while but was contacted by my study place about a trial for people who failed DAA treatment so I thought I would run this by you. As some of you know I failed Harvoni twice. The first was 12 weeks and the second was 24 weeks.
Anyway, has anyone had any experience with the drugs below?
I have been keeping a very close eye on Benitec/Tacere and here in about 6 weeks they will be getting into therapeutic level dosing.
Thanks
Dosing Period
You will be assigned to one of three study Arms (Arm A, B, or C) in a 1:1:1 ratio based on your HCV genotype 1 subtype (1b or non-1b) and the type of DAA treatment that you previously received.
If you are an eligible to participate in the study, you will be enrolled into one of the following arms:
Arm A: ABT-493 200 mg (two 100 mg tablets) + ABT-530 80 mg (two 40 mg tablets) once daily for 12 weeks
Arm B: ABT-493 300 mg (three 100 mg tablets) + ABT-530 120 mg (three 40 mg tablets) once daily + RBV 800 mg (four 200 mg tablets) once daily for 12 weeks
Arm C: ABT-493 300 mg (three 100 mg tablets) + ABT-530 120 mg (three 40 mg tablets) once daily for 12 weeks
And another question which is imporant to me: can the virus MUTATE because of treatment the way that it can be something new unable to be cleared by any drgus?
Just to remind you - I have probably no NS3 RAVs - I have NS5A RAVs L31M and Q54h and genotype 1b.
My consultant believes the best available regimen here will be ABT-530 and ABT-493 which works probably the best for L31M. I trust my consultant although this is interesting what I can get to know here. ABC-530 is probably much better than Velpatasvir here
So if you want to help me just let us discuss this
Do you know anyone with genotype 1b who failed Viekira Exviera?
Pablo,
Yes, not only does this article (kind of) touch on mcmaklin's query, but so do other studies/articles stuffed inside and throughout that GT3's and sof/vel trials thread. As well, there are other articles regarding IL28b CC, CT and TT, and other articles related to RAV's (in one way or another) scattered in different threads all over this site, that are of general subject matter interest, none that outright answer what is the best regime for mcmaklin.
In quest of thee "specific" best "rescue regime" for mcmaklin, it is hard to know with any authority, the subject is so complex. Maybe Tig or malcolm can wing it with some thinking on this.
The article we have here, unfortunately, is absent of and does not highlight NS3/4A VOX (used in conjunction with sof/vel as Gilead's rescue regime) - there are other articles (mostly pro-Gilead) that speak further on this triplet rescue regime that we have yet to see to come to market.
Generally, VEL is proving itself very pan/effective regardless of GT's, CT's/TT's, RAVs, cirrhosis, etc., boasting a host of qualities that allows it to help many people better.
The next good question is (getting ahead of ourselves), if you fail sof/vel, then where do you go? But all the while you have to note that most are NOT failing sof/vel as a treatment-naļve or as a rescue regime, nor are they failing sof/vel/vox as a rescue regime.
I attach a paper on RAVs. I think I may have got it from Canuck.
Hello I am waiting for trials for those who relapsed with ABt-530
Please let me know about RAVS - I know I have L31M - what do you say sometimes "to test RAVs" in "position" 1, 2, 3. What does it mean? I know I can test for specific RAVs in Region Ns5A like L31M or Y93h. Can I test more somewhere?
do you know anyone else who relapsed after Viekira/Exviera with genotype 1b?
-- Edited by mcmaklin on Wednesday 14th of September 2016 02:01:15 PM
I tried to edit this old post, I thought I already done so?, but it didn't work, too old I guess - this was in regard to mcmaklin (about sof/vel, etc.) - to his query about Abby drugs. I've corrected my post now (shown above) - it was OHIO not Ontario.
HR, How are you doing on the newest Abbvie trial? I failed Viekira+Exviera and maybe will be taking part in the 3rd phase of Abbvie Trial that you are taking? How are you? Which group are you in and how do you feel?
Hi,
Don't know what country you are in. Here in Canada, Epclusa seems to have finished trials, but the sof/vel (perhaps with the VOX) I just did, would seem to fit your bill, as far as TT, RAVS.
They are starting to dole it out, spotty, technically it is "approved and on the market" (here and there) U.S. and Canada. One customer on site hails from Alabama, another in Ohio. Canada they have "approved" doing GT 1-6, 12 weeks, cirrhotics add riba. C.
Corrected!
-- Edited by Tig56 on Saturday 27th of August 2016 03:26:17 PM
Hey folk,
Sorry to hear about the RAV's. I think these trials look promising and it gives more options for people. A choice between pills for 12 weeks and a single injection, I'd take the latter any day of the week.
I hope this time you get a cure, nothing worse than disappointment when everyone else seems to be curing...
Good luck!!!!
I replased a month after EOT.
What are options for me now? My consultant says that we know we are waiting for, that the most promising option among patients with NS5A mutations seems to be ABT-530 and ABT-493. That the results of researches show that they work better then other drugs against mutations.
Have you Heard about trials for those who relapsed?
Do you know other who relapsed after Viekira+Exviera?
Genotype 1b, TT, now F1, Relapsed a month after EOT after Viekira+Exviera no Riba 12 weeks in December 2015
As now is 6 months after EOT I know I have RAVs: In Region NS5A I HAVE L31M and Q54h, I do not have Y93H. I have no RAVS in regions NS3.
-- Edited by mcmaklin on Thursday 18th of August 2016 11:42:56 PM
Without Ribavirin both times. I would say there are others but I don't know the number. It cures most folks the first go around so I wouldn't worry too much about my situation.
you failed harvoni 2 times? With or without Ribavirin? I have not heard of this - are there others in the same boat?
Hey Matt,
Yes. TLI is the site that called me. I have not got any info on my RAV profile since last treatment. Ive been feeling good so I haven't been really concerned about it but I think I will start to pursue that info again. They just don't like to give out that info for some reason. I asked about getting my Il28B genotype and they said Gilead has that and they ( TLI) didn't have that info. Also said that that didn't matter on these new DAA's . Well the sign up sheet for this ABBVIE trial wants you to have the IL28b test done which makes me think it might be more important than they let on.
So at any rate this ABBVIE trial is a Phase II so I'm not going to participate. I will wait for Phase 3 or something down the road a bit.
Cochrystal Pharma has some interesting things coming up. The guy from Pharmasett is there. Check out their website.
Good luck with treatment and I want to see a SVR 12 from you. Take care Buddy.
Hey HR
Nice to hear from you again, thanks for posting this info. I assume that TLI is one of the sites for this study. I had been watching these ABBvie DAA's for quite a while, reading data from NATAP it said that in vitro they had a very high barrier to HCV resistance / RAV's so it might be a good fit for either a NS5A or NS3/4 failure. BTW, HR did you get any data on your RAV's profile since your last treatment, it can be very important in choosing your next DAA selection.
matt
Hi,
I had not seen the newest info on that, TT033 was the older article I read. After you pointed it out, I found this short article on TT034. It's an interesting protocol we're definitely going to watch! Thanks for all your info.
http://www.news-medical.net/news/20150429/Fifth-patient-dosed-in-Benitecs-TT-034-Phase-IIIa-clinical-trial-for-prevention-of-HCV-infection.aspx
Tig
Its TT034 and it is an IV infusion. Single shot and you're done. As I said the 6 th patient is going to be dosed in about 6 weeks( fingers crossed no more delays) and this is where efficacy will start to show if it works. There are 5 cohorts and the 6th patient is the first in cohort 3. It's a frustrating trial to watch because of the delays but Lawitz's team has been added to the trial sites so that may help speed things up.
Yes, our friend Ribavirin is still in the mix. The lady I talked to about this Abbvie trial was saying these are second generation drugs? Anyway I just don't want to do 3 trials and it not work. I guess we will see.
Hello,
I haven't heard much on this, but it does appear to be an effective pan genotypic combination. I don't see much discussion on treatment lengths though. I see that our old friend and enemy, Ribavirin is still in the mix. The clinical trial information states that Abbvie is sponsoring the studies on it.
Another thing I found while searching was Benitec's work with TT 033. It's a single dose regimen administered IV. I'm going to look for more current information on that.
http://www.natap.org/2014/AASLD/AASLD_51.htm ABT 493/530
http://www.natap.org/2014/CROI/croi_14.htm ABT 493
http://www.natap.org/2014/CROI/croi_11.htm. ABT 530
Clinical trials:
https://clinicaltrials.gov/ct2/show/NCT02243280?term=Abbvie+%26+Hepatitis+C&recr=Open&no_unk=Y&rank=10
Hey guys,
i haven't posted in a while but was contacted by my study place about a trial for people who failed DAA treatment so I thought I would run this by you. As some of you know I failed Harvoni twice. The first was 12 weeks and the second was 24 weeks.
Anyway, has anyone had any experience with the drugs below?
I have been keeping a very close eye on Benitec/Tacere and here in about 6 weeks they will be getting into therapeutic level dosing.
Thanks
Dosing Period
You will be assigned to one of three study Arms (Arm A, B, or C) in a 1:1:1 ratio based on your HCV genotype 1 subtype (1b or non-1b) and the type of DAA treatment that you previously received.
If you are an eligible to participate in the study, you will be enrolled into one of the following arms:
Arm A: ABT-493 200 mg (two 100 mg tablets) + ABT-530 80 mg (two 40 mg tablets) once daily for 12 weeks
Arm B: ABT-493 300 mg (three 100 mg tablets) + ABT-530 120 mg (three 40 mg tablets) once daily + RBV 800 mg (four 200 mg tablets) once daily for 12 weeks
Arm C: ABT-493 300 mg (three 100 mg tablets) + ABT-530 120 mg (three 40 mg tablets) once daily for 12 weeks