Great results TK,

depending on the lab's type RT PCR LLOQ treshold (eg. in my hosptial it's Abbot with 12 IU/ml LLOQ), thats barely detectable. W4 will be UND i am 100% sure ;)

and baby liver smooth ALT and AST too ;)

2 weeks results are in.

Alt-19

Ast-21

VL- <15 detected 

So I guess the only way it gets better is <15 undetected?

I'm not really sure what the difference is between the two? Anyone?

This sounds great TK. 

Three weeks already and feeling good. This is the news we so much like to hear along with good Lab work.

You got this!

Hi TK,

WoW, you are flyin' through this Tx ... congrats on 3 wks!

Keep us posted on the Labs ... best of luck on 'em.

Dave

You're really moving now Rich! We're all eager to see your upcoming results. If you get tired of those 5 hours of sleep at night, send em my way, lol! Good luck, half way is on the way!!!

Day 21 today! 25% of treatment is done and besides only getting about 5 hrs of sleep a night, I feel fine. I'll post up my 2 week blood work as soon as I get it (probably Thursday). I hope everyone is doing well!

TK 

Amazing result so soon, Rich, I bet you haven`t stopped smiling yet!

You have good reason to be happy with how it`s going so far, this is powerful stuff!  Congrats! 

Thanks for the kind words everyone! It feels really good to have normal liver levels for the first time in more then 15 years. And since I was under 15 after 7 days and today was day 16 I'm probably already totally undetected. I had my 2 week blood work done yesterday so next week I'll have those results. Then I'll have week 4 test, week8, week 12, then 12 weeks post tx and 24 weeks post. I truly believe gilead hit a home run with the velpatasvir! I can't feel the dragon taking its last breath!

Hey Rich

Great to read of your first lab tests, your VL is right where is should be (so low that it can hardly be detected) your going to do just fine.

matt

great news! Seems Velpatasvir is indeed Gilead's Daclatasvir killer (poor BMS) :)

Hey Rich,

Wow! That's incredible! I think you fell into your own pot of gold, outstanding news. Let us know when you hear the rest. The ALT/AST are superb. Can you feel that big old smile coming from that happy liver? Or maybe it's the frown of a soon to be defeated Dragon. Congrats on the great news! 

Got vl test results back after 7 pills of the sof/vel! Hcv rna is >15 detected!

Ast-22

Alt-17

-- Edited by tkflex36 on Thursday 21st of January 2016 01:09:34 PM

Wow this does sound exciting Super Harvoni and Bullet Train, I know I bitched at Gilead a lot. But I am grateful to be cured. With all this new stuff coming out maybe the prices will have to come down. Anybody know if they are coming down? If this is more expensive than Harvoni? Will insurance cover it the same way? Something to think about?

Best of luck TK if Wasn't cured I'd be right there with you  Be safe and be cured

BillS

Going back down here I see it is  a Gilead drug  Hmmm forget what i said about the price things  lol

Super Harvoni sounds great  best of luck TK

-- Edited by Bills on Tuesday 19th of January 2016 11:31:43 PM

Best of luck on those results TK, I get the feeling that this whole trial is going to be nothing but Great news for you.

I believe you're on the Bullet Train ...

Be Well,

Dave

that explains :)

No that was from 2 weeks before tx and the day I started tx. I'll know the results of after one week of tx tomorrow!

Hi TK,

so your base ALT was 59 and @ w1 it was 52? I have expected more from w1 to be honest, but lets wait w4 results.

thanks for updates, very very excited on the Sof/Vel combo, i think you will do great. No sx, smooth ride ;)

best

Hi Everyone,

Well today is day 14 on the sof/vel. And I'm very happy to report thst I still have absolutely zero side effects! I realize it doesn't make for very good updates but I'm sure some people may get some comfort from knowing sides are not always an automatic thing with these meds. I go in for my 2 week blood work tomorrow at 11am. I'm really hoping my 1 week vl test is back, but they did mention it takes like 5 business days for the vl test results. 14 hour work day today for me, hope you all have a great day!

TK 

One week blood work taken yesterday. My vl wasn't back yet from the day I started but my lft was. My starting alt was 59 and ast was 52 so pretty good. I can't wait to get the week one vl test results back.

Hey Rich,

I'll clean up the Dremel and diamond bits and warm up the Lear jet. Let me know when you've had enough of that tooth! 

Sounds like everything is going the best way possible, keep it up! I'm curious to know your results too, so keep us up to date. Good luck and enjoy your time as the Energizer Bunny!

Rich, Looks like  you pulled a good arm on the trial.  24 weeks will get the job done. At week 10 in my last trial I had a molar/filling fall apart. With just two weeks to go I dident want to rock the boat, so I kept it to myself. Yesterday I spent 2 hrs in the Dentist chair having a crown build up and a temp installed. Had that happened early in treatment I would have reported it to the study and they would have OK"d antibiotics .  It was just so close to the end of treatment,it did not hurt,so I decited to get it done at the end of treatment.

Glade your feeling well, and able to work. Daily noon atom bombs going off ! That sounds good!  Keep up the good work.  RC

keep us posted! :) When is your first PCR due? w1 or w2? Can't wait for some data to see how Sof+Vel goes vs Sof+Dac :) exciting!

best

Hey everyone!

It's day 7 and all is well. I go for one week blood work tomorrow and will get my exact results form 12/21 and 1/6 the day I started tx. Tig I'm thinking that diamond bit dremmel might be exactly what I need..lol I started a new job like 3 days after I started tx, been working 10 hour days with energy to spare, I'm really hoping things stay going this good!

TK

Hey Rich,

How's that tooth? Hang in there bro, sounds like you're on the smooth road to success. Aside from that damn tooth, you're doing great! 

PS: I've got a hammer, chisel and pliers if you need help with that tooth. Oh, I also have a Dremel with diamond bits, we could have you fixed up in no time, lol! We have pulled the teeth out of a few Dragons around here, so you'll be well taken care of, promise! 

Sounds good Tk,

Hhope you got the tooth problem(s) all fixed, I recently went through a whole round of tooth problems but got everything worked on and am back in service now.

Glad to hear that there are virtually no side effects so far with this Tx, that's a big plus!

Thanks for keeping us posted. May you experience smooth sailing the whole journey.

Linux

Hi, I've taken Amoxicillin on every treatment I've been on - it's fine.  Good luck. 

Nirmalee

Hey Rich,

I feel for ya brother! I think it was about week 4 that I had a tooth split in two under a crown and the nerve was comprimised. I was dying from pain. I saw an oral surgeon because my dentist was afraid that my low white count and platelets would cause trouble for both of us. I was on the old stuff and it made a difference then. But my hepatologist said that it was fine, gave the oral surgeon the okay to start me on Amoxicillin and pulled the tooth. I had no problems at all and it had zero affect on my treatment. Just make sure you start eating yogurt while on those antibiotics, your digestive tract will thank you for that! Good luck buddy or should I say "Toothy"? 

Awesome! We have another trailblazer on our team. I'll also be glued to this thread to witness how well "Super Harvoni" takes you into the "land of the dead dragons". Good luck Rich!

Outstanding Rich! We'll be following you closely, so lets keep this thread active. I'm sure a lot of people will be interested in your progress. This is a pan genotypic protocol, as you mentioned and is supposed to be quite effective. All signs are pointing toward SVR buddy, good luck!!

Hey Tk,

If I'm not mistaken, sof/vel is what may soon be marketed for across the board genotype cure (non-genotype specific).

If so, that should be a definite dragon killer.

Re: fibrosure test I'm guessing you mean .029, which is very good, you'll be killing the beast before it even leaves a bad scar on you.

Just think, in 24 weeks you can officially achieve SVR ... right on!

Your documentation will help others down the road, wishing you the very best of luck my friend.

Be Well,

Linux

Edit: Ya "pan genotypic" ... what he said ... ... lol.

So this is it, I was randomized to the 12 week arm of sof/vel and took my first dragon bomb at 12 noon today. I'll update my most recent bloods in my sig later, but my fibrosure test done 2 weeks ago was a .29 or F1, and VL was 509,000. I got caught up in the moment and forgot to ask my lft results, but I go back next week so I'll be sure to get them. This thread will serve as my tx log including sides, updated tests, etc. I really look forward to the world of SVR and the land of the dead dragons!