Best of wishes and luck to those choosing to fore-go the present treatments, they are no "picnic" and there can be long term effects (particularly from the interferon) that nobody can possibly anticipate, until such effects are upon you.
mallani said
Oct 17, 2012
Hi Michaele, Respect your decision- we are the only ones who can determine whether we want Rx. Keep in touch. XX
LC said
Oct 17, 2012
Check this out Michaele... You might not be waiting too long.
Even more exciting are the early results with IFN-free and QUAD regimens. A pilot study of 24 weeks of once-daily daclatasvir (NS5a inhibitor) plus twicedaily asunaprevir (NS3/4a protease inhibitor) (DUAL DAA therapy), without either PEGIFN or RBV, achieved SVR of 100 percent in 21 Japanese patients infected with HCV GT 1b who were null responders to a prior course of PEGIFN/RBV.6 In a small preliminary study of U.S. patients, 24 weeks of DUAL DAA treatment was ineffective against HCV GT 1a. But, the addition of PEGIFN/RBV to DUAL (QUAD) yielded SVR12 of 100 percent.7 Many DUAL, QUAD, multi-DAA and IFN-free regimens are currently under investigation.
When will these promising treatments become available?
Several are already in phase III of clinical development and some may be available as soon as 2013 or 2014.
The first to conclude phase III testing will likely be triple therapy using the next generation of protease inhibitors (TMC-435, BI-201335) for HCV GT 1 and an interferon-free regimen of a nucleoside NS5b polymerase inhibitor (GS-7977 [formerly PSI-7977]) with ribavirin for HCV GTs 2 and 3. Other DAAs in or nearing phase III development include additional protease inhibitors (danoprevir, asunaprevir, vaniprevir,ABT-450, others), NS5a inhibitors (daclatasvir, others), nucleoside NS5b polymerase inhibitors (mericitibine, others), and non-nucleoside NS5b polymerase inhibitors (many).
-- Edited by Cinnamon Girl on Thursday 18th of October 2012 10:11:05 PM
greenqueen said
Oct 16, 2012
Hi Michaele,
I'm sure you took everything into account when making this decision and dealing with your other problems must take a lot of strength!
You look after yourself and don't forget we're all here for you
Love Steff xx
JoAnneh said
Oct 16, 2012
It's pays to be proactive in our care! Wishing all the best! Thanks for letting us know JoAnne
LC said
Oct 16, 2012
I am waiting too. I don't want to go through the side effects if it can be avoided. I think there are better drugs on the way.
Michaele said
Oct 16, 2012
God bless all of you suffering with this disease, on tx , off tx , caregivers. After alot of thought Ive decided to delay treatment. Im not as strong or as brave as all of you , and I darn well know I would stop. So rather than ruin my chances for cure in the future by developing mutant strains, Ive decided to wait. I have a laundry list of reasons, its not just a few reasons. But I'll hang around and cheer you on and give comfort if I can Thank You all for being there Michaele
Cinnamon Girl said
Oct 16, 2012
Hi Michaele, I can understand why you`ve made this decision although you`re probably braver and stronger than you think! When and whether or not to go for tx is a decision we all have to make for ourselves, and you have other health problems to take into account as well.
I wish you all the very best for your future, hope you stay around. Remember we`re here for you anytime!
~ Jill xx
-- Edited by Cinnamon Girl on Tuesday 16th of October 2012 09:05:59 PM
Michaele said
Oct 16, 2012
LC, and Iris my adult children dont want me to do it either. I have alot of heath issues and am bipolar , I also live alone. I feel that I was in shock when i said I'd do it. The more I researched the tx the more I saw the contraindications , and I have most of them. I feel the Drs should have done more eval of my issues before ordering the drugs. Had more face to face with me about concerns. My thyroid is off, my platelets were down, my high blood pressure is not controlled, I have Hx of angina and minor heart attack; I was anorexic and my electrolytes went a muck. Doing a Karen Carpenter. Im depressed as heck. There is more, but the list is to long, But I feel pretty good. I think Id be ok without the interferon, so I'll wait. Being geneo 1b Grade 1-2 Stage 2-3 doesnt help, but I can deal with that. Good luck to you. Michaele
-- Edited by Michaele on Tuesday 16th of October 2012 04:57:44 PM
Iris Dragonfly said
Oct 16, 2012
I'm there with you ladies. We can hang. And we can cheer, laugh, cry and scream together, K? There is so much to learn here, and I can so empathize with what everyone is going through.
Blessings, Iris
-- Edited by Iris Dragonfly on Tuesday 16th of October 2012 04:58:13 PM
Best of wishes and luck to those choosing to fore-go the present treatments, they are no "picnic" and there can be long term effects (particularly from the interferon) that nobody can possibly anticipate, until such effects are upon you.
Hi Michaele, Respect your decision- we are the only ones who can determine whether we want Rx. Keep in touch. XX
Check this out Michaele...
You might not be waiting too long.
http://hepatitiscnewdrugresearch.com/chronic-hepatitis-c-treat-or-wait.html -
Even more exciting are the early results with IFN-free and QUAD regimens. A pilot study of 24 weeks of once-daily daclatasvir
(NS5a inhibitor) plus twicedaily asunaprevir (NS3/4a protease inhibitor) (DUAL DAA therapy), without either PEGIFN or RBV, achieved SVR of 100 percent in 21 Japanese patients infected with HCV GT 1b who were null responders to a prior
course of PEGIFN/RBV.6 In a small preliminary study of U.S. patients, 24 weeks of DUAL DAA treatment was ineffective against HCV GT 1a. But, the addition of PEGIFN/RBV to DUAL (QUAD) yielded SVR12 of 100 percent.7 Many DUAL, QUAD,
multi-DAA and IFN-free regimens are currently under investigation.
When will these promising treatments become available?
Several are already in phase III of clinical development and some may be available as soon as 2013 or 2014.
The first to conclude phase III testing will likely be triple therapy using the next generation of protease inhibitors (TMC-435, BI-201335) for HCV GT 1 and an interferon-free regimen of a nucleoside NS5b polymerase inhibitor (GS-7977 [formerly PSI-7977]) with ribavirin for HCV GTs 2 and 3. Other DAAs in or nearing phase III development include additional protease inhibitors (danoprevir, asunaprevir, vaniprevir,ABT-450, others), NS5a inhibitors (daclatasvir, others), nucleoside NS5b polymerase inhibitors (mericitibine, others), and non-nucleoside NS5b polymerase inhibitors (many).
Table: Future Regimens- Speculations on the Availability, Rates of SVR, Duration of Treatment and Tolerability of
Future blaah-blaah-blah...
-- Edited by Cinnamon Girl on Thursday 18th of October 2012 10:11:05 PM
Hi Michaele,
I'm sure you took everything into account when making this decision and dealing with your other problems must take a lot of strength!
You look after yourself and don't forget we're all here for you
Love Steff xx
Wishing all the best! Thanks for letting us know
JoAnne
I am waiting too. I don't want to go through the side effects if it can be avoided. I think there are better drugs on the way.
God bless all of you suffering with this disease, on tx , off tx , caregivers. After alot of thought Ive decided to delay treatment. Im not as strong or as brave as all of you , and I darn well know I would stop. So rather than ruin my chances for cure in the future by developing mutant strains, Ive decided to wait. I have a laundry list of reasons, its not just a few reasons. But I'll hang around and cheer you on and give comfort if I can Thank You all for being there Michaele
Hi Michaele, I can understand why you`ve made this decision although you`re probably braver and stronger than you think! When and whether or not to go for tx is a decision we all have to make for ourselves, and you have other health problems to take into account as well.
I wish you all the very best for your future, hope you stay around. Remember we`re here for you anytime!
~ Jill xx
-- Edited by Cinnamon Girl on Tuesday 16th of October 2012 09:05:59 PM
LC, and Iris my adult children dont want me to do it either. I have alot of heath issues and am bipolar , I also live alone. I feel that I was in shock when i said I'd do it. The more I researched the tx the more I saw the contraindications , and I have most of them. I feel the Drs should have done more eval of my issues before ordering the drugs. Had more face to face with me about concerns. My thyroid is off, my platelets were down, my high blood pressure is not controlled, I have Hx of angina and minor heart attack; I was anorexic and my electrolytes went a muck. Doing a Karen Carpenter. Im depressed as heck. There is more, but the list is to long, But I feel pretty good. I think Id be ok without the interferon, so I'll wait. Being geneo 1b Grade 1-2 Stage 2-3 doesnt help, but I can deal with that. Good luck to you. Michaele
-- Edited by Michaele on Tuesday 16th of October 2012 04:57:44 PM
I'm there with you ladies. We can hang. And we can cheer, laugh, cry and scream together, K? There is so much to learn here, and I can so empathize with what everyone is going through.
Blessings, Iris
-- Edited by Iris Dragonfly on Tuesday 16th of October 2012 04:58:13 PM