scary topic indeed. Speaking of hidden virus remains, have you managed to find out in what Pathology issue was that case presented for HCV "leftovers" in different tissues and organs postmortem?
cheers
mallani said
Sep 1, 2013
Hi Matt,
'Occult HCV infection' is a scarey topic. It basically means detectable HCV in the liver and blood monocytes ( using high resolution assays), in the presence of Undet. blood HCV. I have done previous posts relating to SVR, and possible persistence of tiny amounts of virus in the body. This term is fairly new, and has been found in two situations.
1. Apparently healthy people may have 'occult HCV infection'. They may be HCV Antibody -ve, have an Undet. VL, have normal or abnormal LFT's and have no hepatitis risk factors. The virus may be any Genotype. They are true 'carriers'. Obviously, screening of blood donors remains a slight worry.
2. HCV patients who have been treated and achieved SVR, still have a tiny chance of relapse. This may be due to re-activation of remaining rests of virus, in the liver, monocytes and possible other organs.
I hope this will be clarified by more research.
Previous studies of SVR were only on patients who had used Peg and Riba. Mutations were not a concern. Now, with the DAA's, RAV's are a new topic. That is why this is an interesting article. Cheers.
Matt Chris said
Sep 1, 2013
Hello Malcolm
Thanks for that link about the durability of triple therapy after achieving SVR.
Both my trial doctor and my new Hepatologist thinks there is a place for a Interferon type product (immune system booster) with HCV treatment especially with cirrhotic patients, to help them fight any left over (hiding) HCV with long term treatment.
This report did mention something I read before that I know very little about that is the term "occult HCV infection" I assume that it's means an undiscovered type of HCV that they have not yet identified.
Malcolm do you have any insight on that?
Matt
mallani said
Sep 1, 2013
Hi all,
There have been countless studies reporting the results of SVR using Peg. and Riba. This is the first report I have seen of the SVR benefits using triple Rx. As DAA's have only been around for a short time, obviously the numbers are small, but the results are reassuring.
Hi Malcolm,
scary topic indeed. Speaking of hidden virus remains, have you managed to find out in what Pathology issue was that case presented for HCV "leftovers" in different tissues and organs postmortem?
cheers
Hi Matt,
'Occult HCV infection' is a scarey topic. It basically means detectable HCV in the liver and blood monocytes ( using high resolution assays), in the presence of Undet. blood HCV. I have done previous posts relating to SVR, and possible persistence of tiny amounts of virus in the body. This term is fairly new, and has been found in two situations.
1. Apparently healthy people may have 'occult HCV infection'. They may be HCV Antibody -ve, have an Undet. VL, have normal or abnormal LFT's and have no hepatitis risk factors. The virus may be any Genotype. They are true 'carriers'. Obviously, screening of blood donors remains a slight worry.
2. HCV patients who have been treated and achieved SVR, still have a tiny chance of relapse. This may be due to re-activation of remaining rests of virus, in the liver, monocytes and possible other organs.
I hope this will be clarified by more research.
Previous studies of SVR were only on patients who had used Peg and Riba. Mutations were not a concern. Now, with the DAA's, RAV's are a new topic. That is why this is an interesting article. Cheers.
Hello Malcolm
Thanks for that link about the durability of triple therapy after achieving SVR.
Both my trial doctor and my new Hepatologist thinks there is a place for a Interferon type product (immune system booster) with HCV treatment especially with cirrhotic patients, to help them fight any left over (hiding) HCV with long term treatment.
This report did mention something I read before that I know very little about that is the term "occult HCV infection" I assume that it's means an undiscovered type of HCV that they have not yet identified.
Malcolm do you have any insight on that?
Matt
Hi all,
There have been countless studies reporting the results of SVR using Peg. and Riba. This is the first report I have seen of the SVR benefits using triple Rx. As DAA's have only been around for a short time, obviously the numbers are small, but the results are reassuring.
http://www.natap.org/2013/HCV/073113_04.htm