Hi Robert, welcome from me too, and thanks for your introduction and background information. I can well understand why you`ve waited for a chance to treat the Hep C without interferon, it`s certainly not the easiest drug to tolerate.
Well done for getting into this study, that`s great news! Trial participants don`t usually have a say in which arm they`re allocated to, but the main thing is that you`ve got into this trial and I wish you all the best of luck. Do keep us updated, and feel free to start a new topic in the `Clinical Trial Participants` forum area where we can follow your progress.
PS - I`ve joined both of your current threads together, so as to avoid duplicate replies. ~ Jill
robertsamx said
Jan 26, 2014
The 3 i was speaking of (sofosbuvir,ribavirin,peg. ) the study has 3 arms, 16 weeks sofos,ribav. 24 weeks sofos,ribva. or the 12 weeks of peg,sofos,ribva. I got a call this morning that i was in the study and will be on arm 1--- 16 weeks sofos and ribva.
Tig said
Jan 25, 2014
Hello Robert,
Can you tell me what 3 drug treatment you're referring to? With your CT alelle, your reaction to treatment with Interferon sits squarely in the middle of the three alleles, CC, CT and TT. After all the recent advances with DAA's, I don't know if the rates of SVR are that much better if you add Interferon. If I had a choice and the rates of success were comparable between Tx with or without INT, I'd pass personally. Interferon is not my friend. It's a harsh medication with some unpleasant sx's.
With your recent fibroscan and biopsy results, you should hopefully be approved for treatment without too much grief from insurance. It's apparent that you need to get started and put a stop to any further damage. I'm going to include some data for you to read on your question. Good luck and welcome!
Good luck with treatment. Which arm did you get on? Being cirrhotic and CT genotype, 24 weeks is recommended. Cheers.
robertsamx said
Jan 25, 2014
Robert. 57 m Northwest USA.diag ( non A ) ( Non b ) in 1983. In 1995 it was diag as hep c. then typed geno 3a in 2001. IL28B is CT. Fibro on 12-6-13 is 37. Biopsy1-15-14 stage 4 Made some poor choices in the early 80"s and will now pay the piper. I have always felt good, dident think hep c was taking a toll on me. Had load test that were anywhere from 8m to 300k My AST has always been high in the 150"s and my ALT 300 to 400 Im a type II diabetic using insulen.I have that fairly well under controll. Im not overweight. I felt so good I dident look into treatment because of all the horror stories about treatment drugs SX . Working and treatment dident sound good, so i thought I would wait for retirement.Also the new drugs coming down the pipe seemed a better choice, and worth waiting for. I started looking into the GILEAD trials because the SOFOSBUVIR cought my attention, like the answer to SX. Three mounths ago I started e-mailing different study locations. Went through the screening and fast forward to today, I got the call to schedule my DAY 1 visit, the day I take my first study drugs. Im gratefull and hopefull. I like golf,mid sixties muscle cars.Wife of 28 years and two cats. I think now I will jump over to the trial participation forum, and keep you all updated on how it goes!! Thanks R.C.
robertsamx said
Jan 21, 2014
I was wondering with the high 37 fibro, wouldent the 3 drug treatment be the best? RC
mallani said
Jan 21, 2014
Hi Robert,
A Fibroscan score of 37 is very high, and consistent with cirrhosis. I would be looking for the longest treatment duration- 24 weeks. Best of luck.
robertsamx said
Jan 20, 2014
Im looking into treatment for 3a, looking at trials. one trial has 3 arms. (12 week sofos,riv,peg) (16 weeks sofos,riv) and the third is (24 weeks sofos,riv) GILIAD is puting on the trial.
I have had hep 3a for 30+ years, never been treated, my fibro scan was 37 one month ago. alt 440 the other one is 250. my quan load is 1.8mil, has been as high as 9mil, and as low as 320K, but that was years ago. If i could get into this trial which arm should i hope for?? thanks all RC
Hi Robert, welcome from me too, and thanks for your introduction and background information. I can well understand why you`ve waited for a chance to treat the Hep C without interferon, it`s certainly not the easiest drug to tolerate.
Well done for getting into this study, that`s great news! Trial participants don`t usually have a say in which arm they`re allocated to, but the main thing is that you`ve got into this trial and I wish you all the best of luck. Do keep us updated, and feel free to start a new topic in the `Clinical Trial Participants` forum area where we can follow your progress.
PS - I`ve joined both of your current threads together, so as to avoid duplicate replies. ~ Jill
The 3 i was speaking of (sofosbuvir,ribavirin,peg. ) the study has 3 arms, 16 weeks sofos,ribav. 24 weeks sofos,ribva. or the 12 weeks of peg,sofos,ribva. I got a call this morning that i was in the study and will be on arm 1--- 16 weeks sofos and ribva.
Hello Robert,
Can you tell me what 3 drug treatment you're referring to? With your CT alelle, your reaction to treatment with Interferon sits squarely in the middle of the three alleles, CC, CT and TT. After all the recent advances with DAA's, I don't know if the rates of SVR are that much better if you add Interferon. If I had a choice and the rates of success were comparable between Tx with or without INT, I'd pass personally. Interferon is not my friend. It's a harsh medication with some unpleasant sx's.
With your recent fibroscan and biopsy results, you should hopefully be approved for treatment without too much grief from insurance. It's apparent that you need to get started and put a stop to any further damage. I'm going to include some data for you to read on your question. Good luck and welcome!
http://mobile.aidsmap.com/Sofosbuvirribavirin-for-24-weeks-cures-most-genotype-3-hepatitis-C-patients-adding-interferon-may-help-difficult-to-treat/page/2803799
Tig
16 weeks, sofosbuvir and ribavirin ARM 1
Hi Robert,
Good luck with treatment. Which arm did you get on? Being cirrhotic and CT genotype, 24 weeks is recommended. Cheers.
Robert. 57 m Northwest USA.diag ( non A ) ( Non b ) in 1983. In 1995 it was diag as hep c. then typed geno 3a in 2001. IL28B is CT. Fibro on 12-6-13 is 37. Biopsy1-15-14 stage 4 Made some poor choices in the early 80"s and will now pay the piper. I have always felt good, dident think hep c was taking a toll on me. Had load test that were anywhere from 8m to 300k My AST has always been high in the 150"s and my ALT 300 to 400 Im a type II diabetic using insulen.I have that fairly well under controll. Im not overweight. I felt so good I dident look into treatment because of all the horror stories about treatment drugs SX . Working and treatment dident sound good, so i thought I would wait for retirement.Also the new drugs coming down the pipe seemed a better choice, and worth waiting for. I started looking into the GILEAD trials because the SOFOSBUVIR cought my attention, like the answer to SX. Three mounths ago I started e-mailing different study locations. Went through the screening and fast forward to today, I got the call to schedule my DAY 1 visit, the day I take my first study drugs. Im gratefull and hopefull. I like golf,mid sixties muscle cars.Wife of 28 years and two cats. I think now I will jump over to the trial participation forum, and keep you all updated on how it goes!! Thanks R.C.
I was wondering with the high 37 fibro, wouldent the 3 drug treatment be the best? RC
Hi Robert,
A Fibroscan score of 37 is very high, and consistent with cirrhosis. I would be looking for the longest treatment duration- 24 weeks. Best of luck.
Im looking into treatment for 3a, looking at trials. one trial has 3 arms. (12 week sofos,riv,peg) (16 weeks sofos,riv) and the third is (24 weeks sofos,riv) GILIAD is puting on the trial.
I have had hep 3a for 30+ years, never been treated, my fibro scan was 37 one month ago. alt 440 the other one is 250. my quan load is 1.8mil, has been as high as 9mil, and as low as 320K, but that was years ago. If i could get into this trial which arm should i hope for?? thanks all RC