yep, I had my IR tested several times during peg tx and even after for a while.
Got it under control for tx and was still a non-responder.
oh well.
dm
drummerman said
Jul 29, 2015
"It seems that it is no longer a factor in these days of the DAA's."
Hope your right malani, cause I just don't want to adjust my diet. I like carbs waayyyy too much!
dm
mallani said
Jul 29, 2015
Hi Jack,
You're quite correct- there is little mention of IR in the latest research.
IR is very common in chronic HepC patients, with various studies reporting incidences of 30-75%. This is thought to be a direct effect by the virus on the Insulin signalling pathways. IR is associated with steatosis, particularly in Genotype 3, type 2 diabetes and induces fibrosis and causes an increased risk of HCC. In the old Interferon days, IR was associated with a decreased chance of SVR. All patients had a fasting Insulin and glucose done at my clinic.
It seems that it is no longer a factor in these days of the DAA's. However, I think all new patients should have a fasting Insulin done at some stage.
drummerman said
Jul 28, 2015
I remember when I treated in 2008 there was a lot of discussion regarding steatosis and insulin resistance. Many believed that these conditions made it more difficult to a achieve svr.
I'm not seeing anything about that now and am wondering if the way the new drugs work in such a different way that these conditions are no longer considered a factor.
I ask, because I am IR and am wondering if I should address it. I did bring it way down to normal when I was on peg/riba, ao I know how to do it (diet and exercise, ugh).
I am not overweight, don't have steatosis, don't smoke , don't drink, not diabetic and in good health.
any thoughts, insights, etc. would be appreciated.
yep, I had my IR tested several times during peg tx and even after for a while.
Got it under control for tx and was still a non-responder.
oh well.
dm
Hope your right malani, cause I just don't want to adjust my diet. I like carbs waayyyy too much!
dm
Hi Jack,
You're quite correct- there is little mention of IR in the latest research.
IR is very common in chronic HepC patients, with various studies reporting incidences of 30-75%. This is thought to be a direct effect by the virus on the Insulin signalling pathways. IR is associated with steatosis, particularly in Genotype 3, type 2 diabetes and induces fibrosis and causes an increased risk of HCC. In the old Interferon days, IR was associated with a decreased chance of SVR. All patients had a fasting Insulin and glucose done at my clinic.
It seems that it is no longer a factor in these days of the DAA's. However, I think all new patients should have a fasting Insulin done at some stage.
I remember when I treated in 2008 there was a lot of discussion regarding steatosis and insulin resistance. Many believed that these conditions made it more difficult to a achieve svr.
I'm not seeing anything about that now and am wondering if the way the new drugs work in such a different way that these conditions are no longer considered a factor.
I ask, because I am IR and am wondering if I should address it. I did bring it way down to normal when I was on peg/riba, ao I know how to do it (diet and exercise, ugh).
I am not overweight, don't have steatosis, don't smoke , don't drink, not diabetic and in good health.
any thoughts, insights, etc. would be appreciated.
dm