There are scores of articles, professional and editorial opinions on the efficacy of Harvoni +\- Ribavirin. You could wear out a pair of glasses looking at them all. I find the Clinical Trials website and the cumulative data from Gilead and the ION trials to be the most informative in answering your question. I'm going to include the ION results and the link to it. If you need additional information, I'll do my best to track it down from additional sources.
Well if that is the best they can do I guess I will have to take it. LOL Thanks!
JimmyK
wendyo said
May 4, 2016
Thanks for posting that said the youngster. Being brief as on phone ...computer off due to our thunderstorms. Encouraging stats for sure!
Tig said
May 4, 2016
Hi Jimmy,
There are scores of articles, professional and editorial opinions on the efficacy of Harvoni +\- Ribavirin. You could wear out a pair of glasses looking at them all. I find the Clinical Trials website and the cumulative data from Gilead and the ION trials to be the most informative in answering your question. I'm going to include the ION results and the link to it. If you need additional information, I'll do my best to track it down from additional sources.
Great news. Is there a breakdown by treatment duration. 8, 12, 24?
Tig said
Apr 4, 2016
The rates of success (SVR) just keep impressing with the Harvoni protocol. Here's an update regarding the great success they have found in the GT 1 population age 65 and older. They use the term "elderly", but I think they must be mistaken! Anyway, it's a good and positive report for everyone, regardless of age!
The overall SVR12 rate of all patients treated with ledipasvir/sofosbuvir with or without ribavirin was 97%. The SVR12 rate was slightly greater in patients older than 65 years (98%; 95% CI, 95-99) compared with younger patients (97%; 95% CI, 96-98). In the treatment-naive patients, both elderly and younger patients experienced the same SVR12 (97%). For treatment-experienced patients, SVR12 for patients younger than 65 years was 98% compared with 99% in patients older than 65 years.
http://ipsite.org/3grq
Canuck said
Mar 22, 2016
Tig,
Yes. Good. Interesting (on many levels), and for many, what with all our recent and ongoing questions and discussions on cirrhosis, compensated/decompensated, regeneration, and "prognosis" and "long term outcomes" (found salted everywhere throughout the site). I found the bit about the importance of the the post 24 week SVR now being superceded by the post 12 week SVR what with the onslaught of the many new/newer DAA treatments. I like to read someone re-stating the importance of long term following. C.
Tig said
Mar 21, 2016
This is a very informative article and I recommend it. It discusses the impact SVR has on our future health and well being. They discuss the incidence of fibrosis regression and the clear advantages of beating the Dragon. Check it out!
http://ipsite.org/3g61
Shadowfax said
Feb 4, 2016
Interesting article and thank you for sharing it.
It would be great if the doctors can be more active with regards to getting in other drugs and generics so they can actually help their patients. I do have to think what the repercussions might be for them by doing that when the drug is not yet FDA approved.
One of the best memes I ever saw goes something like this. "For every drug the FDA takes off the market, They approved it prior"
How much money is flowing back and forth between all the organizations and doctors. I think as patients, we need to be active and do as much as we can for ourselves to push everyone involved or in the way of us getting the health care we need.
Tig said
Feb 4, 2016
I found an interesting article/blog update from Greg Jefferies that you might enjoy reading.
Our member Suziq, mentioned taking a look at this website and I thought a post directing you to it would be a good idea. You'll find loads of current information and recommendations there and I think you should spend a moment looking at their many offerings of info. This website has been around for a long time and it's a good idea to go back when you think about it and look to see what has been added since your last visit. I'm always amazed at how fast this new research and the treatment recommendations associated with it are coming. Thanks to Susan for her recommendations.
SOF/LDV 24 weeks 99.1% (108/109)
Well if that is the best they can do I guess I will have to take it. LOL Thanks!
JimmyK
Hi Jimmy,
There are scores of articles, professional and editorial opinions on the efficacy of Harvoni +\- Ribavirin. You could wear out a pair of glasses looking at them all. I find the Clinical Trials website and the cumulative data from Gilead and the ION trials to be the most informative in answering your question. I'm going to include the ION results and the link to it. If you need additional information, I'll do my best to track it down from additional sources.
Gilead Announces SVR12 Rates
Clinical Trials Sofosbuvir/Ledipasvir
Great news. Is there a breakdown by treatment duration. 8, 12, 24?
The rates of success (SVR) just keep impressing with the Harvoni protocol. Here's an update regarding the great success they have found in the GT 1 population age 65 and older. They use the term "elderly", but I think they must be mistaken! Anyway, it's a good and positive report for everyone, regardless of age!
The overall SVR12 rate of all patients treated with ledipasvir/sofosbuvir with or without ribavirin was 97%. The SVR12 rate was slightly greater in patients older than 65 years (98%; 95% CI, 95-99) compared with younger patients (97%; 95% CI, 96-98). In the treatment-naive patients, both elderly and younger patients experienced the same SVR12 (97%). For treatment-experienced patients, SVR12 for patients younger than 65 years was 98% compared with 99% in patients older than 65 years.
http://ipsite.org/3grq
Tig,
Yes. Good. Interesting (on many levels), and for many, what with all our recent and ongoing questions and discussions on cirrhosis, compensated/decompensated, regeneration, and "prognosis" and "long term outcomes" (found salted everywhere throughout the site). I found the bit about the importance of the the post 24 week SVR now being superceded by the post 12 week SVR what with the onslaught of the many new/newer DAA treatments. I like to read someone re-stating the importance of long term following. C.
This is a very informative article and I recommend it. It discusses the impact SVR has on our future health and well being. They discuss the incidence of fibrosis regression and the clear advantages of beating the Dragon. Check it out!
http://ipsite.org/3g61
Interesting article and thank you for sharing it.
It would be great if the doctors can be more active with regards to getting in other drugs and generics so they can actually help their patients. I do have to think what the repercussions might be for them by doing that when the drug is not yet FDA approved.
One of the best memes I ever saw goes something like this. "For every drug the FDA takes off the market, They approved it prior"
How much money is flowing back and forth between all the organizations and doctors. I think as patients, we need to be active and do as much as we can for ourselves to push everyone involved or in the way of us getting the health care we need.
I found an interesting article/blog update from Greg Jefferies that you might enjoy reading.
Access to Hepatitis C Treatment for Everyone
Hi Everyone,
Our member Suziq, mentioned taking a look at this website and I thought a post directing you to it would be a good idea. You'll find loads of current information and recommendations there and I think you should spend a moment looking at their many offerings of info. This website has been around for a long time and it's a good idea to go back when you think about it and look to see what has been added since your last visit. I'm always amazed at how fast this new research and the treatment recommendations associated with it are coming. Thanks to Susan for her recommendations.
http://www.hivandhepatitis.org/hepatitis-c