Your report is as I mentioned. Your viral load is <12 and unquantifiable (too low to even count) but is still detected, barely. That's fantastic and I'm confident you will be undetected on your next test. Keep drinking lots of water and pay attention to eating a good, balanced diet. We have a lot of good ideas to do that on the forum. If we can help you with anything, let us know! Good luck!
Mohammed said
Feb 3, 2016
I really appreciate you all for your comments . please see my detailed report . the last PCRwas 325000 in November 2015
Hepatitis C Virus by PCR (quantitative)
Test Result Unit Ref. Range
By Real-Time PCR Detected <12 IU/mL Not Detected
This test is intended for use along with clinical presentation and other laboratory findings in the management of patients with chronic HCV infection, also used
to predict the probability of sustained virologic response (SVR) early during a course of antiviral therapy, and to assess viral response to antiviral treatment
(response guided therapy) as measured by changes of HCV RNA levels in serum or EDTA plasma
Methodology Brief:-
Quantification of HCV RNA in serum or plasma using CEAbbott RealTime HCV assay utilizes RT-PCR technology combinedwith homogeneous real time
fluorescent detection for the detection of HCV RNA. The selection of a conserved region of the HCV genome provides for the detection of genotypes 1-6. The
assay is standardized against the Second WHO International Standard for Hepatitis C Virus RNA (NIBSC Code 96/798)and results are reported in International
Units/mL (IU/mL).
This test was developed and its performance characteristics have been determined by Al Borg Medical laboratories Jeddah Saudi Arabia. It has not been
cleared or approved by the FDA. Al Borg Medical Laboratories are regulated under CLIA guidelines (CAP# 7197774) as qualified to perform high complexity
testing. This test is used for clinical purposes. It should not be regarded as investigational or for research.
Limitation
1- The limit of detection (LOD) at 95% confidence: 12 IU/mL.
2- The limit of Quantification (LOQ) of the assay ranges from 12 IU/mLto 100 million IU/mL.
3- Detected <12 IU/mL means that the assay detects the viral RNA but is unable to quantify the number of copies accurately.
4- Rare mutations within the highly conserved regions of the viral genome covered by the testsprimers and/or probes may result in failure to detect the virus.
5- Detection and quantification of HCV RNA is dependent on the number of virus particles present in the specimen and may beaffected by specimen collection
6- A specimen with a result of not detected cannot be presumed to be negative for HCV RNA.
Recommendations:-
Al Borg Medical Laboratories also offers HCV Genotyping and IL-28B polymorphisms tests which can help in predi
Tig said
Feb 2, 2016
Your post does say the lab report said <12 Detected. Are you sure? Take another look and let us know. Many of the new tests have a LLOQ (lowest level of quantification) of 12. So they can't count viral particles any lower than that, but can determine there are a few stragglers remaining. Not a big deal this early in treatment! As Jimmy stated, you are likely undetected by now, so I wouldn't worry about it at all.
JimmyK said
Feb 2, 2016
Ho Mohamed,
Also please keep in mind, <12 is UND. If your were 12 at last blood draw you are now likely UND. Hang in there and no worries, unless you are a Dragon of course. ;)
JimmyK
Tig said
Feb 2, 2016
I agree Mohammed, a viral reduction that low is excellent! Many people don't clear completely until the end of treatment. The huge reduction this early into care, is a good indication of the effectiveness your treatment drugs are having on the virus. You should be encouraged by these results!
Gracie said
Feb 2, 2016
Yes Mohammad, there are some who dont clear at week 4 but go on to clear. And 12 is pretty insignificant as far as viral load goes. The only test that matters is the 12 weeks past. Keep going your doing awesome!
Mohammed said
Feb 2, 2016
I have completed 4 week on Harvoni . I made the PCR and the result was detected 12 I need your help to tell me is the result OK so far
Jaded said
Jan 26, 2016
Tig56 wrote:
I've been looking for something, anything, that might indicate a stimulant component and have found nothing. There are many, many Methyl group references and how they are an Alkyl based substance that is somehow compounded into many things. There seems to be no similarities I can find, that would show any relationship between the Methamphetamine family of drugs and Harvoni. I think the energy increase being noticed by so many is just a metabolic response to the introduction of a very powerful antiviral medication. That's my totally non scientific guess. I think they would be in some very serious trouble if they were introducing a stimulant to someone without proper authorization and identification. Call a compound pharmacist and see if they might be able to explain it better.
Thanks for your reply Tig. I do know for example that methamphetamine has been used medicinally to treat ADHD and obesity. This is due to the fact that Methamphetamine's effects lead to increased energy and alertness as well as loss of appetite. This drug has been FDA approved.
I believe these Harvoni components are not methamphetamines..but I wonder if there are any relationship to components that have the letters "meth" to stimulants. Some...not all...of the side-effects and withdrawal symptoms seem to be similar to Harvoni for many people.
Rare
Agitation
delusions
hallucinations
Incidence not known
Blurred vision
chest discomfort or pain
dark-colored urine
difficulty breathing
dizziness
faintness
false or unusual sense of wellbeing
fast, pounding, or irregular heartbeat or pulse
fever
headache
muscle cramps or spasms
muscle pain or stiffness
pounding in the ears
restlessness
shakiness in the legs, arms, hands, or feet
swelling of the feet or lower legs
trembling or shaking of the hands or feet
trouble sleeping
twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
uncontrolled vocal outbursts and tics
unusual tiredness or weakness
Some of the side effects that can occur with methamphetamine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
Incidence not known
Bad, unusual, or unpleasant (after) taste
change in taste
constipation
decreased interest in sexual intercourse
dry mouth
hives or welts
inability to have or keep an erection
indigestion
itching
loss in sexual ability, desire, drive, or performance
-- Edited by Jaded on Tuesday 26th of January 2016 06:25:52 AM
-- Edited by Jaded on Tuesday 26th of January 2016 06:28:24 AM
Tig said
Jan 26, 2016
I've been looking for something, anything, that might indicate a stimulant component and have found nothing. There are many, many Methyl group references and how they are an Alkyl based substance that is somehow compounded into many things. There seems to be no similarities I can find, that would show any relationship between the Methamphetamine family of drugs and Harvoni. I think the energy increase being noticed by so many is just a metabolic response to the introduction of a very powerful antiviral medication. That's my totally non scientific guess. I think they would be in some very serious trouble if they were introducing a stimulant to someone without proper authorization and identification. Call a compound pharmacist and see if they might be able to explain it better.
Jaded said
Jan 26, 2016
Below is the chemical structure of harvoni. I am wondering if the red coloured ingredients are in any way related to the methamphetamine stimulant. I am trying to understand if what some refer to as the "Harvoni high"...the increase of energy experienced soon after starting tx...might be related to a stimulant nature of the drug and perhaps a crash or withdrawal that some people experience after cessation of it. I realize that this a very technical question that few will be able to answer. Hopefully Mallani will see this but anyone with a chemistry background is welcome to weigh-in on this.
Ledipasvir
The IUPAC name for ledipasvir is Methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate.
It has a molecular formula of C49H54F2N8O6 and a molecular weight of 889.00.
Sofosbuvir
The IUPAC name for sofosbuvir is (S)-Isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)-(phenoxy)phosphorylamino)propanoate. It has a molecular formula of C22H29FN3O9P and a molecular weight of 529.45.
After my 2nd or 3rd day on Harvoni I began to feel greater energy. I couldn't believe it and thought it was the effects of clearing the virus only to have a substantial drop of energy after tx. This seems to happen to some...maybe many. At some point in the day (I am almost now 13 weeks post tx) I begin to fade and have great difficulty feeling awake after my much needed nap. Last night I took a look at chemical structure I posted and began to wonder about the Meth chemicals. I decided to buy some ephedrine and took 8 mg when I woke up and felt better...and this evening when I felt I was beginning to fade a bit a took another 1/2 and was able to avoid a crash. I am wondering if I am experiencing withdrawal from a stimulant. If so it might also explain why some experience an increase of blood pressure...heart palpitations...vertigo...etc???
-- Edited by Jaded on Tuesday 26th of January 2016 05:16:42 AM
-- Edited by Jaded on Tuesday 26th of January 2016 05:17:08 AM
-- Edited by Jaded on Tuesday 26th of January 2016 05:19:16 AM
-- Edited by Jaded on Tuesday 26th of January 2016 05:20:32 AM
-- Edited by Jaded on Tuesday 26th of January 2016 05:59:50 AM
Thanks a lot Tig
Hi Mohammed,
Your report is as I mentioned. Your viral load is <12 and unquantifiable (too low to even count) but is still detected, barely. That's fantastic and I'm confident you will be undetected on your next test. Keep drinking lots of water and pay attention to eating a good, balanced diet. We have a lot of good ideas to do that on the forum. If we can help you with anything, let us know! Good luck!
I really appreciate you all for your comments . please see my detailed report . the last PCR was 325000 in November 2015
Hepatitis C Virus by PCR (quantitative)
Test Result Unit Ref. Range
By Real-Time PCR Detected <12 IU/mL Not Detected
This test is intended for use along with clinical presentation and other laboratory findings in the management of patients with chronic HCV infection, also used
to predict the probability of sustained virologic response (SVR) early during a course of antiviral therapy, and to assess viral response to antiviral treatment
(response guided therapy) as measured by changes of HCV RNA levels in serum or EDTA plasma
Methodology Brief:-
Quantification of HCV RNA in serum or plasma using CEAbbott RealTime HCV assay utilizes RT-PCR technology combinedwith homogeneous real time
fluorescent detection for the detection of HCV RNA. The selection of a conserved region of the HCV genome provides for the detection of genotypes 1-6. The
assay is standardized against the Second WHO International Standard for Hepatitis C Virus RNA (NIBSC Code 96/798)and results are reported in International
Units/mL (IU/mL).
This test was developed and its performance characteristics have been determined by Al Borg Medical laboratories Jeddah Saudi Arabia. It has not been
cleared or approved by the FDA. Al Borg Medical Laboratories are regulated under CLIA guidelines (CAP# 7197774) as qualified to perform high complexity
testing. This test is used for clinical purposes. It should not be regarded as investigational or for research.
Limitation
1- The limit of detection (LOD) at 95% confidence: 12 IU/mL.
2- The limit of Quantification (LOQ) of the assay ranges from 12 IU/mLto 100 million IU/mL.
3- Detected <12 IU/mL means that the assay detects the viral RNA but is unable to quantify the number of copies accurately.
4- Rare mutations within the highly conserved regions of the viral genome covered by the testsprimers and/or probes may result in failure to detect the virus.
5- Detection and quantification of HCV RNA is dependent on the number of virus particles present in the specimen and may beaffected by specimen collection
methods, patient factors (e.g. age, presence of symptoms) and/or stage ofinfection.
6- A specimen with a result of not detected cannot be presumed to be negative for HCV RNA.
Recommendations:-
Al Borg Medical Laboratories also offers HCV Genotyping and IL-28B polymorphisms tests which can help in predi
Your post does say the lab report said <12 Detected. Are you sure? Take another look and let us know. Many of the new tests have a LLOQ (lowest level of quantification) of 12. So they can't count viral particles any lower than that, but can determine there are a few stragglers remaining. Not a big deal this early in treatment! As Jimmy stated, you are likely undetected by now, so I wouldn't worry about it at all.
Ho Mohamed,
Also please keep in mind, <12 is UND. If your were 12 at last blood draw you are now likely UND. Hang in there and no worries, unless you are a Dragon of course. ;)
JimmyK
I agree Mohammed, a viral reduction that low is excellent! Many people don't clear completely until the end of treatment. The huge reduction this early into care, is a good indication of the effectiveness your treatment drugs are having on the virus. You should be encouraged by these results!
Yes Mohammad, there are some who dont clear at week 4 but go on to clear. And 12 is pretty insignificant as far as viral load goes. The only test that matters is the 12 weeks past. Keep going your doing awesome!
Thanks for your reply Tig. I do know for example that methamphetamine has been used medicinally to treat ADHD and obesity. This is due to the fact that Methamphetamine's effects lead to increased energy and alertness as well as loss of appetite. This drug has been FDA approved.
https://en.wikibooks.org/wiki/Structural_Biochemistry/Methamphetamine
I believe these Harvoni components are not methamphetamines..but I wonder if there are any relationship to components that have the letters "meth" to stimulants. Some...not all...of the side-effects and withdrawal symptoms seem to be similar to Harvoni for many people.
Rare
Incidence not known
Some of the side effects that can occur with methamphetamine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
Incidence not known
http://www.drugs.com/sfx/methamphetamine-side-effects.html
Withdrawal:
Symptoms usually consist of fatigue, depression, increased appetite and anxiety. Effects usually last months.
https://en.wikibooks.org/wiki/Structural_Biochemistry/Methamphetamine
-- Edited by Jaded on Tuesday 26th of January 2016 06:25:52 AM
-- Edited by Jaded on Tuesday 26th of January 2016 06:28:24 AM
I've been looking for something, anything, that might indicate a stimulant component and have found nothing. There are many, many Methyl group references and how they are an Alkyl based substance that is somehow compounded into many things. There seems to be no similarities I can find, that would show any relationship between the Methamphetamine family of drugs and Harvoni. I think the energy increase being noticed by so many is just a metabolic response to the introduction of a very powerful antiviral medication. That's my totally non scientific guess. I think they would be in some very serious trouble if they were introducing a stimulant to someone without proper authorization and identification. Call a compound pharmacist and see if they might be able to explain it better.
Below is the chemical structure of harvoni. I am wondering if the red coloured ingredients are in any way related to the methamphetamine stimulant. I am trying to understand if what some refer to as the "Harvoni high"...the increase of energy experienced soon after starting tx...might be related to a stimulant nature of the drug and perhaps a crash or withdrawal that some people experience after cessation of it. I realize that this a very technical question that few will be able to answer. Hopefully Mallani will see this but anyone with a chemistry background is welcome to weigh-in on this.
Ledipasvir
The IUPAC name for ledipasvir is Methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate.
It has a molecular formula of C49H54F2N8O6 and a molecular weight of 889.00.
Sofosbuvir
The IUPAC name for sofosbuvir is (S)-Isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)-(phenoxy)phosphorylamino)propanoate. It has a molecular formula of C22H29FN3O9P and a molecular weight of 529.45.
After my 2nd or 3rd day on Harvoni I began to feel greater energy. I couldn't believe it and thought it was the effects of clearing the virus only to have a substantial drop of energy after tx. This seems to happen to some...maybe many. At some point in the day (I am almost now 13 weeks post tx) I begin to fade and have great difficulty feeling awake after my much needed nap. Last night I took a look at chemical structure I posted and began to wonder about the Meth chemicals. I decided to buy some ephedrine and took 8 mg when I woke up and felt better...and this evening when I felt I was beginning to fade a bit a took another 1/2 and was able to avoid a crash. I am wondering if I am experiencing withdrawal from a stimulant. If so it might also explain why some experience an increase of blood pressure...heart palpitations...vertigo...etc???
-- Edited by Jaded on Tuesday 26th of January 2016 05:16:42 AM
-- Edited by Jaded on Tuesday 26th of January 2016 05:17:08 AM
-- Edited by Jaded on Tuesday 26th of January 2016 05:19:16 AM
-- Edited by Jaded on Tuesday 26th of January 2016 05:20:32 AM
-- Edited by Jaded on Tuesday 26th of January 2016 05:59:50 AM