This is clearly of considerable interest to me.
So far, I
- drink lots of coffee
- reduce BMI
- saw that in an abstract for CROI conference, statins were looked at (Simon et al., a 551)
"In patients with chronic HCV infection, statin use appears to reduce the risk of fibrosis progression
and decrease the risk of incident HCC, in a dose-dependent manner. Atorvastatin and fluvastatin are each
associated with significantly reduced fibrosis progression to cirrhosis, compared to other types of statins.
Further prospective clinical studies with clinical and histological endpoints are needed."
So I will talk to my doc, maybe switch me from rosuvacard to one of these ...
Lastly, and there seems to be an age-old controversy about that, Metformin. Not my field, but a friend of mine (Oxford PhD, biochemist) told me about its diabetes and anti-aging potential. He says most elderly (I am afraid he includes me here) develop some insulin resistance, likely not good re cirrhosis. Well. Furthermore, a large trial is now underway to check the anti-aging hypothesis. Reported in nature.com, I guess these are serious people, "Anti-ageing pill pushed as bona fide drug". Another talking point with my doc ..
Any thoughts/comments?
Cheers, Tom
(yes, I may become a little obsessive, and should get out more)
Matt Chris said
Mar 8, 2016
Hey Peter
That is fantastic news, it would be nice to know what are the factors in reversing cirrhosis, like Malcolm mentioned it can get better or in some cases get worse.
It would make common sense items like diet, staying active physically, getting good sleep and reducing stress all can aid in the recovery.
matt
Peter M said
Mar 7, 2016
Just got a fibroscan after about two years of SVR. Fibroscan score: 5.9 which puts me at F0-F1. My last test was a biopsy in 2008 whicch showed cirrhosis. Before that a biopsy around 2003 showed bridging fibrosis F3.
Shadowfax said
Feb 18, 2016
Every time I read something like this, I just dream a bit and especially the part for cirrhotics since there are a number of us here.
Gracie said
Feb 17, 2016
It appears that fibrosis reversal is most definitely possible. I was reading up on it myself, and some good signs are raising of platelets and lowering of AFP of which I've had both so am very hopeful. I would think lifestyle choices would play a role. Definitely no drinking and regular exercise, low stress and healthy eating would help with your chances. And now that cure is possible for most, the next studies will most definitely be on fibrosis reversal. Let's hope in ten years we are all living with healthy slightly scarred regenerated livers! It is the only organ who can regenerate so chances are great for us!
mallani said
Feb 17, 2016
John,
I understand there will be some updated data shortly.
As of now, the reports state that, after 3 years, 50% show improvement of 1 to 2 stages, 25% are unchanged and 25% show some worsening of the histological features. The research is directed at what factors play a part in these figures, and whether anti-fibrotic agents can help.
The problem now, is that many patients are followed up by FibroScan, Elastography or Biochemical markers, so there will be a bit of doubt.
Post-SVR cirrhotics have a reduced incidence of HCC. Two years ago, I was told my chance of HCC had dropped to twice the normal population incidence. Now that I'm no longer cirrhotic, I think my chances of HCC are only slightly more than the normal population.
It has been shown that, in all post-SVR cirrhotics, portal venous pressure dropped. In other words, if you didn't have varices before treatment, you won't develop them now. Cheers.
JLynch30 said
Feb 17, 2016
Anyone know what the idea is on cirrhosis treatment? Prognosis for cirrhosis after SVR?
So far, I
- drink lots of coffee
- reduce BMI
- saw that in an abstract for CROI conference, statins were looked at (Simon et al., a 551)
"In patients with chronic HCV infection, statin use appears to reduce the risk of fibrosis progression
and decrease the risk of incident HCC, in a dose-dependent manner. Atorvastatin and fluvastatin are each
associated with significantly reduced fibrosis progression to cirrhosis, compared to other types of statins.
Further prospective clinical studies with clinical and histological endpoints are needed."
So I will talk to my doc, maybe switch me from rosuvacard to one of these ...
Lastly, and there seems to be an age-old controversy about that, Metformin. Not my field, but a friend of mine (Oxford PhD, biochemist) told me about its diabetes and anti-aging potential. He says most elderly (I am afraid he includes me here) develop some insulin resistance, likely not good re cirrhosis. Well. Furthermore, a large trial is now underway to check the anti-aging hypothesis. Reported in nature.com, I guess these are serious people, "Anti-ageing pill pushed as bona fide drug". Another talking point with my doc ..
Any thoughts/comments?
Cheers, Tom
(yes, I may become a little obsessive, and should get out more)
Hey Peter
That is fantastic news, it would be nice to know what are the factors in reversing cirrhosis, like Malcolm mentioned it can get better or in some cases get worse.
It would make common sense items like diet, staying active physically, getting good sleep and reducing stress all can aid in the recovery.
matt
Just got a fibroscan after about two years of SVR. Fibroscan score: 5.9 which puts me at F0-F1. My last test was a biopsy in 2008 whicch showed cirrhosis. Before that a biopsy around 2003 showed bridging fibrosis F3.
Every time I read something like this, I just dream a bit and especially the part for cirrhotics since there are a number of us here.
It appears that fibrosis reversal is most definitely possible. I was reading up on it myself, and some good signs are raising of platelets and lowering of AFP of which I've had both so am very hopeful. I would think lifestyle choices would play a role. Definitely no drinking and regular exercise, low stress and healthy eating would help with your chances. And now that cure is possible for most, the next studies will most definitely be on fibrosis reversal. Let's hope in ten years we are all living with healthy slightly scarred regenerated livers! It is the only organ who can regenerate so chances are great for us!
John,
I understand there will be some updated data shortly.
As of now, the reports state that, after 3 years, 50% show improvement of 1 to 2 stages, 25% are unchanged and 25% show some worsening of the histological features. The research is directed at what factors play a part in these figures, and whether anti-fibrotic agents can help.
The problem now, is that many patients are followed up by FibroScan, Elastography or Biochemical markers, so there will be a bit of doubt.
Post-SVR cirrhotics have a reduced incidence of HCC. Two years ago, I was told my chance of HCC had dropped to twice the normal population incidence. Now that I'm no longer cirrhotic, I think my chances of HCC are only slightly more than the normal population.
It has been shown that, in all post-SVR cirrhotics, portal venous pressure dropped. In other words, if you didn't have varices before treatment, you won't develop them now. Cheers.
Anyone know what the idea is on cirrhosis treatment? Prognosis for cirrhosis after SVR?