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Hep C Discussion Forum -> HCV/HBV/HIV Co-Infection -> Phase 3 Ledipasvir/Sofosbuvir Fixed-Dose Combination for 12 Weeks in Subjects With HCV GT 1&4 and HIV co-inf
Post Info TOPIC: Phase 3 Ledipasvir/Sofosbuvir Fixed-Dose Combination for 12 Weeks in Subjects With HCV GT 1&4 and HIV co-inf
Sara


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RE: Phase 3 Ledipasvir/Sofosbuvir Fixed-Dose Combination for 12 Weeks in Subjects With HCV GT 1&4 and HIV co-inf
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Thank you Jill. 



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Sovaldi/Olysio/Riba 2 week vl 16 4 week vl UND! EOT vl UND! EOT+12 SVR!  EOT+24 SVR!!

 
Cinnamon Girl


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Hi Sara!  Thanks for your input and sharing your experience, this is very useful. 

Sorry you didn`t manage to get onto one of these trials yourself, but you should do very well on the Sovaldi/Olysio combo this time around.

Best of luck! 



__________________

Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
Sara


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I tried to get into this study.  Each location is assigned a limited number of spots (five I think) for enrollment.  Of the limited number for each location, only ONE participant can be cirrhotic.  If there is more than one person being considered, basically you are competing for the spot.  I lost out to someone who is half my age.  I do understand this and don't have a problem with it at all.  I was told once the initial spots are filled, additional spots will be assigned if the 300 spots allocated for the entire trial haven't been taken, but the chances of this happening are slim. 

I think this is a great study for those co-infected.  It's the first time I've seen a study that lowered the minimum requirement for platelets.  

If anyone is interested in this trial, I recommend getting screened quickly before the trial fills up and there are no spots left.  Those who are able to participate will be potentially SVR quicker then those waiting for FDA approval!

 



__________________

Sovaldi/Olysio/Riba 2 week vl 16 4 week vl UND! EOT vl UND! EOT+12 SVR!  EOT+24 SVR!!

 
OldenSlow


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Thanks, Maddie. wink



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66 y/o male - Geno 1b - F4 cirrhotic dx 2001 - 16 wk treatment w/ Sovaldi/Olysio/Riba - Und @ EOT+24 SVR

 
maddie


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Thank you Jill.



__________________

Dx. 2005-liver bx.: stg 2/gr 1. at that time  - GT 1a multiple transfusions in 1981.  Started Sovaldi and Olysio 1/16/14  (No prior treatments) Q80K present.  UND week 4,8 and at EOT.   UND at wk 4EOT, Und at wk 8EOT  SVR 12!!!..SVR 24 :-)
Cinnamon Girl


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Hi Maddie, I don`t think anyone`s posted it before and it`s very good information for us to have. 

Thanks!

(Ps - I`ve moved it here to our dedicated HCV/HIV Co-Infection area)



__________________

Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
maddie


Senior Member

Status: Offline
Posts: 210
Date:
Permalink  
 

 

Not sure if someone already posted this but thought it important.  If it is a duplicate I apologize and one of moderators can delete.

http://clinicaltrials.gov/ct2/show/record/NCT02073656?term=hepatitis+c+seattle&recr=Open&rank=8



__________________

Dx. 2005-liver bx.: stg 2/gr 1. at that time  - GT 1a multiple transfusions in 1981.  Started Sovaldi and Olysio 1/16/14  (No prior treatments) Q80K present.  UND week 4,8 and at EOT.   UND at wk 4EOT, Und at wk 8EOT  SVR 12!!!..SVR 24 :-)
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Hep C Discussion Forum -> HCV/HBV/HIV Co-Infection -> Phase 3 Ledipasvir/Sofosbuvir Fixed-Dose Combination for 12 Weeks in Subjects With HCV GT 1&4 and HIV co-inf
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