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Hep C Discussion Forum -> Hep C News -> RIP Incivek
Post Info TOPIC: RIP Incivek
TazKat


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RE: RIP Incivek
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It makes me mad that I went thru that crap. only to relapse. but we did not know the newer would be here so quick or I just did not know. geez.. I could have avoided that poison. oh wellllll..  lol

Peace out

Taz



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TazKat Genotype 1A null responder x 3 riba & iterferon twice, relapsed from Incivek 2012 with only 12 weeks left to do. stage 4 mild cirrhosis 4/25/2014/ started sovaldi riba & interferon.. finished treatment 7/17/14  results 7/25  cleared..

 

 
Isiscat2011


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longld wrote:
I for one am very happy that my wife at 62 now gets free birth control.....and ISIS believes I will take advantage of the mental health coverage <smile>.
Huey wrote:

 The System and the ACA have created a cass socal socity of poor people who get this kind of care and rich that get what ever they want so long as they pay for it. 

Free birth control you say....darn....I was hoping to see a few mini-longids running around.   :)

Now you two rascals are blaming the Affordable Care Act for America's inequitable wealth distribution.  Amazing.  Maybe you can pin global warming on the ACA while you are at it.  Too bad Obama isn't a bit older; you might be able to nail him for the Kennedy assassination!!  biggrin

 



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
longld


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The liberal political class in this country designed and passed the law with no conservative members supporting it.  The were the party for the poor and I trusted them to be 'looking out for the little guy'......I for one am very happy that my wife at 62 now gets free birth control.....and ISIS believes I will take advantage of the mental health coverage <smile>.
Huey wrote:

 The System and the ACA have created a cass socal socity of poor people who get this kind of care and rich that get what ever they want so long as they pay for it.

 Insurance companys will let poor people go untreated and die before they will do any harm to a paying customer.

 



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62 Yrs Old, CHC Geno 3, Cirrhosis, Kidney Transplant (13 yrs), On Sovaldi/Riba Treatment (24 week) since Feb 01,2014

Viral Load 7M on 1/8/2014,  UND at EOT 7/18/2014
Huey


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longld wrote:

I did not say the system we have is perfect - just that it is the best in the world for producing life-saving medicine.   With the ACA, now all uninsured people will have ins and the world will be perfect, like all of the other countries with nationalized healthcare.......

 

I did want us to see that Sovaldi might be a short-lived drug and wonder how many were complaining about the amount of money Incivik was making a few years ago - I was not on the forum at that time....?

 The System and the ACA have created a cass socal socity of poor people who get this kind of care and rich that get what ever they want so long as they pay for it.

 Insurance companys will let poor people go untreated and die before they will do any harm to a paying customer.



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  HCV Genotype 3a , now Psot-Tx was on S/riba. First VL was 5.8 mil on 7-5-13 then "und" at 3.8 weeks. 06/13/14 still und. off meds 3 days back on 7/29 Last pill 08/10/14 SVR+4

 
Isiscat2011


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longld wrote:

I did not say the system we have is perfect - just that it is the best in the world for producing life-saving medicine.   

_________________________________________________________________________________________________________

Yet, people get sicker and sometimes die, because they are unable to access the medicine.  Pharma CEOs and stockholders create nothing; scientists are the innovators. Actual production costs relatively little once the science is in place.  The money pharma spends is overwhelmingly in marketing.

The same innovation could occur for a fraction of what pharma wastes.  Better innovation, in fact, because much of what pharma produces is just junk "me too" drugs that are no better than the last, or worse, drugs that are actually harmful and end up being discontinued.  It isn't a good business model, but it makes a few people rich.  Why we put up with it is the question. 

 

 



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
Isiscat2011


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Lee:  There is no comparison between the profits Vertex generated and the amount Gilead has and will continue to amass.   The total revenue for Incivek was <1.25 billion.  Sovaldi pulled in more than double that in its first quarter.  

Unless it turns out to be a crappy drug, or Gilead proves to be too greedy for its own good, Sovaldi will go the distance.  It may be paired with newer 2nd and 3rd DAAs but Sovaldi will be a staple for the foreseeable future.

 



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
Isiscat2011


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jimbob wrote:

Isis dear, I believe Lee was just being facetious. That little rascal. ...

He's a rascal alright but he is quite serious in his support of the current pharma system (despite the fact that Americans are frequently denied drugs they need).  

I keep trying to persuade him of the errors in his thinking but he just won't budge!! smile



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
longld


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I did not say the system we have is perfect - just that it is the best in the world for producing life-saving medicine.   With the ACA, now all uninsured people will have ins and the world will be perfect, like all of the other countries with nationalized healthcare.......

 

I did want us to see that Sovaldi might be a short-lived drug and wonder how many were complaining about the amount of money Incivik was making a few years ago - I was not on the forum at that time....?



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62 Yrs Old, CHC Geno 3, Cirrhosis, Kidney Transplant (13 yrs), On Sovaldi/Riba Treatment (24 week) since Feb 01,2014

Viral Load 7M on 1/8/2014,  UND at EOT 7/18/2014
jimbob


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Isis dear, I believe Lee was just being facetious. That little rascal. ...

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jimbob: 64 y/o, GT 1A, F1-F2, diagnosed 1996. Since 1970. SOT 3.5 mil VL on 3/10/14 with Sov/Rib/Peg for 12 weeks. Tx naive. UND @ week 4,8,12. EOT 6/2/14.
jimbob


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...I can't help but to wonder big pharma's position if one of them finds a cure for cancer....Will the health system just collapse?

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jimbob: 64 y/o, GT 1A, F1-F2, diagnosed 1996. Since 1970. SOT 3.5 mil VL on 3/10/14 with Sov/Rib/Peg for 12 weeks. Tx naive. UND @ week 4,8,12. EOT 6/2/14.
Isiscat2011


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P.S.   Lee:  With the publication of the new AASLD guidelines on who to treat it is clear that the US, one of the richest countries in the world, has now moved into a rationing system for treating people who have HCV.  HCV is an horrific and life threatening, and let us not forget, an infectious disease. We are now rationing a drug that costs very little to produce, that cannot be considered a scarce resource, under any definition. 

Consequently, we will see people (probably on this message board) who are desperate to be treated but will be denied.  Given the length of time it can take to successfully treat, and often retreat for HCV, there is no question that many will become sicker while they wait.  Some will die because they have already been forced to wait too long.  We will witness these things occurring.  Will you still be singing the praises of the free market system?

HCV patients in the US have become sicker and died waiting for better tx while Gilead intentionally delayed the progress of tx in the name of profits. And this is just in the US.  It does not begin to address the human suffering and death that will continue to happen around the world.  If this is how the pharma "free market" functions then it is clearly in need of some changes.  

 



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
Isiscat2011


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longld wrote:

I love how the free market works!

_________________________________________________________________________________________________________

Yes, I love how the pharma free market works!

If a person can't afford the medication that they or perhaps their child needs, and their 3rd party payer won't pay for it, they don't get it.  

If pharma doesn't see sufficient profit potential in a life saving drug they don't produce it.

Sounds like a great plan to me!   If only we had the choice to buy or not buy life saving drugs the way we can choose to buy or not buy that new computer.

Read this:  http://www.forbes.com/sites/rickungar/2012/02/12/proof-of-the-failure-of-free-markets-in-medicine/ 

 



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
longld


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For those debating about Gilead's greed and twenty year patent life......

 

Incivek had almost 1B$ revenue in the first six months of release (2011) - in less than 4 years they sold the remaining rights to this drug for 150M$ - regardless of patent rights this drug is finished making money (with the exception of a small intl market).   The income from the sale is funding a new drug for cystic fibrosis - I love how the free market works!

 

cheers, lee



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62 Yrs Old, CHC Geno 3, Cirrhosis, Kidney Transplant (13 yrs), On Sovaldi/Riba Treatment (24 week) since Feb 01,2014

Viral Load 7M on 1/8/2014,  UND at EOT 7/18/2014
Isiscat2011


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Uh Oh......here we go again!!   



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
Ekkiemom


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Can I hear a big AMEN to that!!



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Gator Man


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New Hep C Drugs Lead to Cancellation of Vertexs Incivek

 

Following the release of newer, improved therapies to treat hepatitis C virus (HCV), Vertex Pharmaceuticals has decided to discontinue Incivek (telaprevir), The Wall Street Journal reports. Vertex announced in an August 11 letter to physicians that the NS3/4A protease inhibitor will come off the market October 16. In May, Vertex announced it was ending its hep C research and development program. 

Released to much fanfare in 2011, Incivek had a rapid rise and fall. After the initial glut of people with hep C received treatmentmore than 100,000 people took the drug all toldnews began to emerge of forthcoming drugs in the pipeline that offered improved success rates as well as the chance for treating without interferon. (Incivek must be paired with interferon, which has flu-like side effects which are a major deterrent to those considering treatment.) Consequently, Incivek sales declined as physicians warehoused patients in anticipation of the release of Gilead Sciences Sovaldi (sofosbuvir) and Janssens Olysio (simeprevir), which were each approved at the end of 2013.

While Gilead sold a record-shattering $5.78 billion during the first six months of 2014, Vertex sold just $13.2 million of Incivek during that same time, which amounted to a 96 percent fall from the $361.4 million in sales during the first half of 2013.

Express Scripts, the largest pharmacy benefits manager in the country, recently announced that Incivek was one of 66 medications that would be removed from the companys national formulary in 2015.



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Geno 1b, compensated cirrhotic, 54 yo, prior null responder. Pre tx VL approx 595,000, tx with Sovaldi/Olysio (no Riba) started 1/8/14. VL 40 @ 2 weeks, UND @ 4 weeks. Still UND @ EOT + 1 year.

Gator Man SVR12, Dragon 0, Final Score.
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