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Hep C Discussion Forum -> Hep C News -> New Updated AASLD Guidelines includes Harvoni and new AbbVie drugs
Post Info TOPIC: New Updated AASLD Guidelines includes Harvoni and new AbbVie drugs
skewedButNotBroken


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New Updated AASLD Guidelines includes Harvoni and new AbbVie drugs
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If you sign up for tweets from Dr. Robert Gish, you will be notified anytime something major happens in the world of hep c: https://twitter.com/RobertGish



-- Edited by skewedButNotBroken on Monday 22nd of December 2014 02:19:43 AM

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Diag. with hep c in 1992; A3:F2;  GT 1a; IL28B CT; VL 900k, ALT 150, AST 100 on 8/5/2014; SOT 9/5/2014  S/O ---VL 127 after 6 days; VL detected on day 18 but < 15.; --> UND @ EOT+ 1 year SVR!
Beacon


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Josh,

There was no grand announcement that the AASLD had updated their guidelines but I

knew it supposed to be sometime this month. It looks like here in the USA that

after the publishing of these guidelines, the final nail has been put in

interferon's casket, but ribavirin is still useful.



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GT 1a, was tx naïve, cirrhotic(Fibrosure), 64 y.o. Started Harvoni 12/12/14 for 12 wks. EOT weeks 4, 13, and 24 HCV not detected! HVC not detected EOT plus one year.

A smooth sea doesn't make for a skillful sailor.

 
Josh Haynie


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ca-ching ... nice find BEACON... i tried clicking on the more text links and it blocked me :( so i found this http://www.hcvguidelines.org/

password sumthin or other pantheon.....

 

and this http://www.hcvguidelines.org/node/71

 

 anyway thanks for finding that :)   

                                               



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genotype 1  HCV 4,958,318 iu/ml    HCV Log updated soon  iu/ml------5'10 135lbs 9-15-83  genotype 1 since 2002----Pendleton,Oregon
Beacon


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These are the new AASLD guidelines posted:

Compensated Cirrhosis Genotype 1A

Three options with similar efficacy in general are recommended for treatment-naive patients with HCV genotype 1a infection (listed in alphabetic order; see text).

Daily fixed-dose combination of ledipasvir (90 mg)/sofosbuvir (400 mg) for 12 weeks* is recommended for treatment-naive patients with HCV genotype 1a infection.
*see text for further detail on length of treatment

Rating: Class I, Level A

Daily fixed-dose combination of paritaprevir (150 mg)/ritonavir (100 mg)/ombitasvir (25 mg) plus twice-daily dosed dasabuvir (250 mg) and weight-based RBV (1000 mg [<75 kg] to 1200 mg [>75 mg]) for 12 weeks (no cirrhosis) or 24 weeks (cirrhosis [see also Cirrhosis Section]) is recommended for treatment-naive patients with HCV genotype 1a infection.

Rating: Class I, Level A

Daily sofosbuvir (400 mg) plus simeprevir (150 mg) with or without weight-based RBV (1000 mg [<75 kg] to 1200 mg [>75 kg]) for 12 weeks (no cirrhosis) or 24 weeks (cirrhosis [see also Cirrhosis Section]) is recommended for treatment-naive patients with HCV genotype 1a infection.

 

Genotype 1B

 

Three options with similar efficacy in general are recommended for treatment-naive patients with HCV genotype 1b infection (listed in alphabetic order; see text).

Daily fixed-dose combination of ledipasvir (90 mg)/sofosbuvir (400 mg) for 12 weeks* is recommended for treatment-naive patients with HCV genotype 1b infection.
*see text for further detail on length of treatment

Rating: Class I, Level A

Daily fixed-dose combination of paritaprevir (150 mg)/ritonavir (100 mg)/ombitasvir (25 mg) plus twice-daily dosed dasabuvir (250 mg) for 12 weeks is recommended for treatment-naive patients with HCV genotype 1b infection. Rating: Class I, Level A The addition of weight-based RBV (1000 mg [<75kg] to 1200 mg [>75 mg]) is recommended in patients with cirrhosis. (See also Cirrhosis Section)

Rating: Class I, Level A

Daily sofosbuvir (400 mg) plus simeprevir (150 mg) for 12 weeks (no cirrhosis) or 24 weeks (cirrhosis [See also Cirrhosis Section]) is recommended for treatment-naive patients with HCV genotype 1b infection

Anyway I didn't want this to be too long so all the other updated treatment guidelines are posted on their website.

p.s. don't bother to click on any links in this post as they don't work.

 

 



-- Edited by Beacon on Monday 22nd of December 2014 01:47:45 AM

__________________

GT 1a, was tx naïve, cirrhotic(Fibrosure), 64 y.o. Started Harvoni 12/12/14 for 12 wks. EOT weeks 4, 13, and 24 HCV not detected! HVC not detected EOT plus one year.

A smooth sea doesn't make for a skillful sailor.

 
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