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Hep C Discussion Forum -> Post Treatment -> SOF/VEL/GS-9857 trial - EOT week 12 - I'm done
Post Info TOPIC: SOF/VEL/GS-9857 trial - EOT week 12 - I'm done
Sydhanrahan


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RE: SOF/VEL/GS-9857 trial - EOT week 12 - I'm done
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A good story Michael, about to get even better with Dave cruising into SVR a day after you.

Syd

biggrin



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Contracted Hep C 1969. Genome Type 2, treatment naive. Began 12 week RIBA/sof/Dac on 12/11/15. Cirrhosis. VL before treatment 4m. Treatment extended another 12 weeks without Riba. No virus detected at 9 weeks.
Linuxter


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Hey Michael,

We'll soon be arriving at the SVR Station, please put your seats in an upright position and prepare for your arrival.

My start date was Jan 20th 2016 so I'm a day behind ya (12wk Sof/Riba).

Nice to finally be approaching that final, wonderful news of SVR ... smile

See ya at the train station ...

 

Dave



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63yy,HCV,2b,F3-A1, Sof/Riba,12wks Tx   SOT: 1/20/16, HCV-RNA 9,816,581, ALT 56, Hb 14.6

4wk: HCV-RNA <15 Detected, ALT 15, AST 17, Hb 13.6 EOT: 4/12/16, ALT 18 , Hb 12.9176a2f85d05d9c965eafe199f2ba9ba5.jpg SVR Achieved 7/8/16

 
robertsamx


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Hi Michael, Haven't heard from you ? How are you doing? Hope the last couple months have been good, you know with the dragon gone and all you should be on top of the world. Congratulations!!   RC



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 M-64) 3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18   
webtomass


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Thanks Wendy and all.



__________________

Contracted 1980's - blood transfusion
F4 FibroScore 28 - Genotype 4 - VL 233,000 at beginning of treatment
Treatment: Sofosbuvir, Velpatasvir, GS-9857
Gilead clinical trial - NCT02607735
Start: 01/19/16
12 weeks treatment
Relapsed - Vieira Pak+Rib 2015
webtomass


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Fibroscan I can get anytime no waiting but its better to wait at a minimum 3 months post treatment for improvement scores. As for the MRI or CATscan I get them done once a year and yes there is an MRI being booked as a follow up. Glad your treatment is going well also. ITs been a breeze for me. My head is not at right place at night time after a full day work and sleeping issues which both are pre-existing will hopefully correct themselves after a while. Anyone who would ask me about this treatment I would put them at ease it is by far the least impacting treatment I've ever taken. I think this is the golden treatment. Gilled will come out on top by end of year once more results are published... EASL conference also had some great numbers to show. Looking forward to SVR12 results. Cheers. M 



__________________

Contracted 1980's - blood transfusion
F4 FibroScore 28 - Genotype 4 - VL 233,000 at beginning of treatment
Treatment: Sofosbuvir, Velpatasvir, GS-9857
Gilead clinical trial - NCT02607735
Start: 01/19/16
12 weeks treatment
Relapsed - Vieira Pak+Rib 2015
webtomass


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Cheers all and thanks for your support.. focusing on SVR 12. Healthy and willing. Cheers. Michael



__________________

Contracted 1980's - blood transfusion
F4 FibroScore 28 - Genotype 4 - VL 233,000 at beginning of treatment
Treatment: Sofosbuvir, Velpatasvir, GS-9857
Gilead clinical trial - NCT02607735
Start: 01/19/16
12 weeks treatment
Relapsed - Vieira Pak+Rib 2015
Canuck


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uh, oh,

sorry

i talk funny

didn't mean to express myself that way!

I should be more careful with my pre-s and q's. smile C.



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)
wmlj1960


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Canuck wrote:

Webtomass,

Forgot to mention, or rather, assumed you already knew of, met, read, noted "pablito" recently. Same regime as us, a relapser, and maybe the person you already referred to? I just forgot to put his name down in my last post to you. C. 

 I almost misunderstood this at first an freaked out. That would be 'prior relapser' - on Interferon / Ribavirin, correct? smile



__________________

60 yo, geno 1a, Dx 1994 HCV-HIV co-inf, Dx 2013 decompensated cirrhosis
Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52 = SVR

Mike

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Canuck


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Webtomass,

Forgot to mention, or rather, assumed you already knew of, met, read, noted "pablito" recently. Same regime as us, a relapser, and maybe the person you already referred to? I just forgot to put his name down in my last post to you. C. 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)
Observer


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smile That is AWESOME!smile

bless

A



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61 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

4 years.... successful dragon slayer 
Canuck


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All done!! Well done!! Congrats. Nice for you to be on the "other side" and finished. You had a spectacular ride. You killed it!

I agree with you, that this regime is going to be the next great thing, for many to come. TN or TE. I feel you and I and tkflex56 were very fortunate indeed to get Gileads new drugs. (tkflex did not get the gs-9857 arm)

I have been so pleased to hear, all along, how well your trail went for you, in every way, and, with no sides to speak of. I hope your pre-existing sleep problem will start to improve now and in the near future.

Your sof/vel/gs-9857 trial was nearly identical to mine, except of course mine is only 8 weeks (my last day is May 4). It also differed in that I was able to know and post my week 1, 2 and 4 VL's, where as you could only post your week 8 and 12 VL's. My only regret (for your trial) was that they could not allow all your VL's to be known. But we, along with you, were of course expecting a good response, just based soley on this regime's track record, on the nice early decreases seen in your ALT's/AST's, and based on your 6th sense of feeling "it was gone". Nice you were able to sense this.

You well deserve this cure after your prior disappointment (it should have worked the first time 'round!, but, you've done it now!). The follow-ups will put you more and more at ease with your new found health and life. Repeat fibroscans and MRI's will be reassuring. I am wondering something though ... your next fibroscan and MRI, were they a "standard expected part" of your "normal trial follow-up protocol", or, did you only get them because you specifically requested them and your doc agreed? Perhaps they are part of your trial - but I do not see any follow-up fibroscan, nor MRI, nor even a repeat abdominal ultrasound in my post-treatment follow-up (I never had an MRI). Just wondering if your fibroscan and MRI are "trial generated". If I find out that no more "trial generated" fibroscans or ultrasounds are due for me, then I will be asking for some future ones.

I have not heard of any other prior relapsers who have gone onto our regime as a re-treatment - I doubt there are many out there to find (as yet), if I do find anyone else, I will post here or PM you. You were lucky to find one other person! Now you can possibly compare notes, and follow one another. Perhaps you could ask this person if they would also like to share here too? 

I am very, very pleased for you and tkflex56 (as I am for myself), and I hope we all keep each other posted. smile C. 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)
Linuxter


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Nice Job Michael,

This is the stuff that all of our dreams are made of ...

"EOT" & "Not Detected" ... Yay!  headbang.gif

 

Happy for ya,

Dave



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63yy,HCV,2b,F3-A1, Sof/Riba,12wks Tx   SOT: 1/20/16, HCV-RNA 9,816,581, ALT 56, Hb 14.6

4wk: HCV-RNA <15 Detected, ALT 15, AST 17, Hb 13.6 EOT: 4/12/16, ALT 18 , Hb 12.9176a2f85d05d9c965eafe199f2ba9ba5.jpg SVR Achieved 7/8/16

 
wmlj1960


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Way to go Michael. You've done a great job sticking with your treatment and it's paying off, but we're not done yet. I too have low platelets (74 currently) and we need to continue to take good care of our bodies so our platelets can continue to improve as our livers slowly regenerate.

 All the researching can cease. Relapse no longer needs to be in our vocabulary. Be good to yourself and live your life. We'll be waiting for your arrival in SVRville in 12 weeks. Life is good! smile



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60 yo, geno 1a, Dx 1994 HCV-HIV co-inf, Dx 2013 decompensated cirrhosis
Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52 = SVR

Mike

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Tig


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Congratulations Michael! EOT is a great destination and SVR is a nice place to stay when you arrive in a few short months. I have every confidence that this has been successful, the rates of SVR are phenomenal with this protocol.

We'll be anxiously waiting on your next labs. If they're as good as your last, we'll all be thrilled! Good luck smile



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Cinnamon Girl


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Hi Michael, what wonderful news, congrats on your EOT undetected!!   w00t.gif

Your lab results look great, and how amazing to see how your liver enzymes, ALT and AST, have steadily dropped and your platelet levels have been gradually rising, you must be very happy indeed, and I`m very happy for you!

You`ve responded so well to this trial, and it`s looking very promising indeed for SVR12!

I`m glad your journey went so smoothly for you, let us know when you have your next results.  Best of luck! 

 

(Ps - I`ve moved this thread from `New Members` Area` to `Post Treatment` for you)



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
wendyo


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Awesome news webtomas! Congrats. Look forward to hearing you results of the upcoming testing and saying prayers for good results!

wendy



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Wendy 53 y/o, DX 1994, geno 1A F1

1999 TX 1 - Inter -non responder 2001 TX 2 - Peg + Riba - viral load tripled and taken off

T3:  Harvoni 12 weeks Sept. 19, 2015 ALT 41 AST 30 VL 541800 UND at EOT and SVR 24 ALT 18 AST 26 platelets 223

 
webtomass


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Hi all,

A quick update from the Golden TGV Bullet Train that arrived at its final destination gate on April11. The service in first class has been tremendous. Feeling very good no side effects. I'm done. Undetected (see below). I'm interested 3 months post EOT but something inside tells me not this time. Its gone. I'm feeling great but hard to fall asleep thats my liver condition syndrome. Next 3-6 months will tell. Booked fibroscan a couple months down the road no use doing one now you see results after 3 months as far as improvements are concerned. Also going for an MRI in a couple of months. I'm trying to find others on this treatment or similar treatment who had relapse also. If you can point me to them that be great I think I found one...Cheers and thanks for your support you are a great bunch of people. 

PRIOR TREATMENT:

ALT: 65
AST: 54
Eosinophil 7.5 a little high (range:0.0-6.8)
Platelets 86 (Low)
HCV RNA: 336,000

WEEK 1

ALT: 55
AST: 50
Eosinophil 0.18 (normal range)
Platelets 100 (Low)
HCV RNA: Here's the kicker, study specifics blocker are inlace for subjects results BUT will know more next week.

WEEK 2

ALT: 49
AST: 38
Platelets 102
HCV RNA: Unknown

WEEK 4

ALT: 37
AST: 28
Platelets: 104
HCV RNA: UNKNOWN - specifics blockers are in place for subjects results. Week 8 visit on March 14.

WEEK 8

ALT: 39
AST: 30
Platelets: 107
HCV RNA: Undetected

WEEK 12

ALT: 33
AST: 28
Platelets: 102
HCV RNA: Undetected



__________________

Contracted 1980's - blood transfusion
F4 FibroScore 28 - Genotype 4 - VL 233,000 at beginning of treatment
Treatment: Sofosbuvir, Velpatasvir, GS-9857
Gilead clinical trial - NCT02607735
Start: 01/19/16
12 weeks treatment
Relapsed - Vieira Pak+Rib 2015
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