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Hep C Discussion Forum -> General Discussion -> In ELECTRON trial, 100% of hard-to-treat patients cured with sofosbuvir/ledipasvir plus ribavirin or GS-9669
Post Info TOPIC: In ELECTRON trial, 100% of hard-to-treat patients cured with sofosbuvir/ledipasvir plus ribavirin or GS-9669
Matt Chris


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In ELECTRON trial, 100% of hard-to-treat patients cured with sofosbuvir/ledipasvir plus ribavirin or GS-9669
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Hey all

This link is about the same electron study but a whole lot easy to read

http://hivandhepatitis.com/hcv-treatment/experimental-hcv-drugs/4387-100-of-hard-to-treat-patients-cured-with-sofosbuvirledipasvir-plus-ribavirin-or-gs-9669

One of the points that I have been seeing out of some of these studys is that the baseline reading on Rav's before treatment with these newer DAA's has no consequence on outcome.

Which could mean retreatment with similar protease inhibitor but newer/better will be possible.

Matt



-- Edited by Matt Chris on Saturday 9th of November 2013 02:27:52 PM

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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
marktrux


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I think this another article about the same thing but it's still interesting. 

 

http://www.everydayhealth.com/hepatitis/drug-combo-cures-high-percent-of-hep-c-patients-6209.aspx?xid=aol_eh-news_6_20131104_&aolcat=HLT



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KCCO

 

 
Biggyb


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Right on Zlik, were all gonna beat this soon. I am guessing within 5 years.



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58 yo..Relapsed in 99 and again in 2004. Started triple therapy with Victrelis July 22,2012.  genotype 1a. week 8,12,16,24 VL Undetectable..E.O.T -- 6-22-2013,,,EOT + 24., UND. 

SVR !!!

 

~Bob~
Zlikster


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:) so soon it will be time to say goodbye to HCV.



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GT 3 dg. 08-2012 / FibroScan: 5 kPa F1 / FibroTest: F0-1 A1 / SoC TX: PegInt 120mcg+Riba 1000mg UND from w8 relapse EOT+4w
01-2016 Sof+Dac+Riba UND from w8, SVR24!
Loopy Lisa


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I am so happy for you guys, death to Hep C for you all would be amazing, now to find a innoculation for the unstable RNA virus! x



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Genotype: 3b

VL.�over 15, 000 000

Failed TX 2014: Interferon/Riba.

Cured using Sof/Dak combination.

I can eat cake again! <3 
Matt Chris


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Hey Bills

I felt the same way when I read this report.

It made my day and filled up my hope cup for the week.

Between this news about Gilead and Mercks new combo there will be a lot of new treatments than will not involve Interferon in the coming months and for you Bill its a very good chance that a phase III trial for cirrhotic patients that have failed other triply therapy will be available this coming next 12 months.  Especially because these results were based on a small study group

A great day for all HCV treatment waiters.

Matt



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
ucbgal


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wow!!!! this is great news for nonresponders to triple. less sx, shorter duration of treatment and quicker svr.

 

there was an article in the nytimes this past weekend  discussing "compassionate plea " to drug companies . evidently one can write a personal plea/letter requesting a new drug that's not fda approved for their condition. reading the article was an eye opener. perhaps this can be an option for  those who aren't in clinical trials.

 

the article was in either the health or business section of  sunday november 3,2013.

 

sandy,ucbgal

 



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Bills


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WOW 

That's what I'm waiting for too. 

All I can say is When  and When  and When ??? 

Just hearing this is a relief Hope is really on its way now 

BillS 



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Bills

Harvoni started 12-12-14 for 24 wks PrevTX Geno 1 stage 3 cirrhosis - non resp Int/ ribv. Started Trial  in Aug 2011 -July 2012 into Incivek relapsed  Feb 2013 Had 72 weeks on interferon & Riba.

tonib


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This is what I have been hoping for!!  



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 geno 1, started peg and riba 7/5/13, now 29th day is vicrellis ***tonib VL started 6 million, after 5 weeks 374,000, after 8 weeks 150,000....the big test for VL is 9/27 at 12 weeks  TAKEN OFF THERAPY JUST NOT WORKING FOR ME...12 WEEKS STILL HAVE 9000 VL
lauralou57


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These are outstanding results.

Thank you for posting this.

SVR 100% for everyone!



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Terry


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Those appear to be great results for that trial. It's looking like Gilead is going to become the leader is the race for getting rid of this virus once and for all. And I like the idea of the GS-9669 not causing the anaemia that the ribavirin does. I am five weeks after treatment and yet still very tired and unmotivated.



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Geno Type 1a stage 4 cirrhosis EOT 52 weeks SVR !!
suziq


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Hi Matt,

They are achieving great results in the latest trials, aren't they??  I am very hopeful after Merck released my trial data.  Down with Hep C--the new meds are gonna kill you!!!

SuziQ



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Geno 1A  Age 82 Treatment naive Cirrhotic Told I had liver disease in 1966. Diagnosed as Hep C 1999.Started Merck clinical trial with Riba on 9/9/2013 Week 1 and 2 <25  Weeks 4, 8, 12,16,18 UND.  EOT Jan 14,2014  EOT +12 UND   JULY 1 2014 EOT+24= SVR
Matt Chris


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Hey All

Great news from Gilead's presentation at the AASLD about cirrhotic patient treatments.

Here is a small excerpt from the article

In the first comparison, 100% of people with cirrhosis treated with sofosbuvir/ledipasvir plus ribavirin achieved SVR12, compared to only 70% of those treated with sofosbuvir/ledipasvir alone. Presence of resistance-associated mutations at baseline did not appear to reduce treatment efficacy.

In the second comparison, 100% of patients with advanced fibrosis or cirrhosis achieved SVR12 when treated with sofosbuvir/ledipasvir plus either ribavirin or GS-9669. While response rates were the same in both arms, haemoglobin levels dropped significantly amongst people taking ribavirin but remained stable amongst GS-9669 recipients.

checkout the article fromHCV NEWS BLOG link -http://mobile.aidsmap.com/page/2787227

matt 



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
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