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Post Info TOPIC: 3a treatment
Cinnamon Girl


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RE: 3a treatment
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Hi Robert, welcome from me too, and thanks for your introduction and background information.  I can well understand why you`ve waited for a chance to treat the Hep C without interferon, it`s certainly not the easiest drug to tolerate. 

Well done for getting into this study, that`s great news!  Trial participants don`t usually have a say in which arm they`re allocated to, but the main thing is that you`ve got into this trial and I wish you all the best of luck.  Do keep us updated, and feel free to start a new topic in the `Clinical Trial Participants` forum area where we can follow your progress. 

PS - I`ve joined both of your current threads together, so as to avoid duplicate replies. ~ Jill



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
robertsamx


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The 3 i was speaking of (sofosbuvir,ribavirin,peg. )   the study has 3 arms,  16 weeks sofos,ribav.  24 weeks sofos,ribva.  or the 12 weeks of peg,sofos,ribva.   I got a call this morning that i was in the study and will be on arm 1--- 16 weeks sofos and ribva.



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 M-64) 3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18   
Tig


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Hello Robert,

Can you tell me what 3 drug treatment you're referring to? With your CT alelle, your reaction to treatment with Interferon sits squarely in the middle of the three alleles, CC, CT and TT. After all the recent advances with DAA's, I don't know if the rates of SVR are that much better if you add Interferon. If I had a choice and the rates of success were comparable between Tx with or without INT, I'd pass personally. Interferon is not my friend. It's a harsh medication with some unpleasant sx's.  

With your recent fibroscan and biopsy results, you should hopefully be approved for treatment without too much grief from insurance. It's apparent that you need to get started and put a stop to any further damage. I'm going to include some data for you to read on your question. Good luck and welcome!

http://mobile.aidsmap.com/Sofosbuvirribavirin-for-24-weeks-cures-most-genotype-3-hepatitis-C-patients-adding-interferon-may-help-difficult-to-treat/page/2803799

Tig



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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robertsamx


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16 weeks,  sofosbuvir and ribavirin     ARM 1



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mallani


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Hi Robert,

Good luck with treatment. Which arm did you get on? Being cirrhotic and CT genotype, 24 weeks is recommended. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
robertsamx


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Robert. 57 m Northwest USA.diag ( non A ) ( Non b ) in 1983.  In 1995  it was diag  as hep c.  then  typed geno 3a  in 2001. IL28B is CT.  Fibro on 12-6-13 is 37. Biopsy1-15-14 stage 4   Made some poor choices in the early 80"s and will now pay the piper.  I have always felt good, dident think hep c was taking a toll on me. Had load test that were anywhere from 8m to 300k  My AST has always been high in the 150"s and my  ALT 300 to 400  Im a type II diabetic using insulen.I have that fairly well under controll.  Im not overweight. I felt so good I dident look into treatment because of all the horror stories about treatment drugs SX .  Working and treatment dident sound good, so i thought I would wait for retirement.Also the new drugs coming down the pipe seemed a better choice, and worth waiting for.  I started looking into the GILEAD trials because the SOFOSBUVIR cought my attention, like the answer to SX. Three mounths ago I started e-mailing different study locations. Went through the screening and fast forward to today, I got the call to schedule my DAY 1 visit, the day I take my first study drugs.  Im gratefull and hopefull.  I like golf,mid sixties muscle cars.Wife of 28 years and two cats. I think now I will jump over to the trial participation forum, and keep you all updated on how it goes!!  Thanks    R.C.



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robertsamx


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RE: 3a treatment
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I was wondering with the high 37 fibro, wouldent the 3 drug treatment be the best?     RC



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mallani


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Hi Robert,

A Fibroscan score of 37 is very high, and consistent with cirrhosis. I would be looking for the longest treatment duration- 24 weeks. Best of luck.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
robertsamx


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Im looking into treatment for 3a, looking at trials.  one trial has 3 arms.  (12 week sofos,riv,peg)  (16 weeks sofos,riv) and the third is (24 weeks  sofos,riv)  GILIAD is puting on the trial.

I have had hep 3a for 30+ years, never been treated, my fibro scan was 37 one month ago. alt 440  the other one is 250.   my quan load is 1.8mil, has been as high as 9mil, and as low as 320K, but that was years ago.    If i could get into this trial which arm should i hope for??   thanks all  RC 



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