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Hep C Discussion Forum -> Hep C News -> T-cells
Post Info TOPIC: T-cells
Isiscat2011


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RE: T-cells
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Very interesting stuff.  So, the question will be whether to treat the hepc before transplant or wait until after the new liver has time to acclimate to its new environment.  

The other side of the coin in whether treating the hepc before transplant might eliminate the need for the transplant completely or merely postpone it; another variable that there is probably no "one size fits all" answer to.  



__________________

Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
OldenSlow


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Thanks, Huey. Interesting stuff. Along the same lines, an article about how the Hep C virus itself may reduce the need for post-transplant immunosuppresants:

Silver Lining for Transplant Patients?

From the article:

"In background information supplied with the study, the researchers explained that because the immune system is suppressed by medications, hepatitis C actually flourishes after a transplant, causing rapid damage to the new liver.

However, if the immune-suppressing drugs are not given, hepatitis C appears to help a liver recipient accept the new organ -- even better than immunosuppressive medications would.

All this is due to a common viral trick that hepatitis C uses to avoid getting spotted by the immune system. According to the new study, the virus "rewires" immune cells to reduce their function -- essentially performing the immune-squelching work that immunosuppressive drugs do.

"This is part of the virus' immune evasion strategy and can be observed in a part of patients developing chronic hepatitis C," Bohne said.

The result is an environment in which immune response is blunted against the replacement liver because hepatitis C has taught the body to ignore the new organ."



__________________

66 y/o male - Geno 1b - F4 cirrhotic dx 2001 - 16 wk treatment w/ Sovaldi/Olysio/Riba - Und @ EOT+24 SVR

 
Huey


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http://news.yahoo.com/designer-t-cells-fight-viruses-transplants-191027539.html

 

This may be of some interest to those with transplants.



__________________

  HCV Genotype 3a , now Psot-Tx was on S/riba. First VL was 5.8 mil on 7-5-13 then "und" at 3.8 weeks. 06/13/14 still und. off meds 3 days back on 7/29 Last pill 08/10/14 SVR+4

 
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