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Hep C Discussion Forum -> Post Treatment -> Failed Harvoni, anyone else?
Post Info TOPIC: Failed Harvoni, anyone else?
Have you failed a DAA treatment? [7 vote(s)]

Failed Sovaldi
14.3%
Failed Sovaldi + Rib or other
57.1%
Failed Harvoni
28.6%
Failed Harvoni + Rib
0.0%
Failed Viekira Pak
0.0%
angelseven


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RE: Failed Harvoni, anyone else?
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I hope everything goes perfectly for you!!!!!  Keep us updated!!!
Groupergetter wrote:

 Hi Angel, still anxiously waiting my EOT +12 the end of July,  I saw my doc this week for MRI results, and discussed the real world Harvoni relapse rates (at least what they are seeing)  This is a teaching hospital and they have treated hundreds with Harvoni.  She stated they are seeing about a 95% SVR 12 rate, very similar to the clinical trials.  

She also stated there were very few relapses if a person was undetected at EOT + 4 and that she was only aware of a couple.  She qualified this stating we were still in the early stages of larger sample results.  The good news is that there are new meds on the way.  Folks that have failed Harvoni will reach their destination, just may take longer.   Take care.

 



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62 year old female      1a, f1-2, had virus 40 years   STARTED HARVONI for 8 weeks 11/19/14, relapsed one month after tx  ended in 1/15.  Fibrosis level was only .5 after fibroscan 12/15. Began treatment with Mavyret on January 20, 2018 for 16 weeks!  Ending May 12.
Groupergetter


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 Hi Angel, still anxiously waiting my EOT +12 the end of July,  I saw my doc this week for MRI results, and discussed the real world Harvoni relapse rates (at least what they are seeing)  This is a teaching hospital and they have treated hundreds with Harvoni.  She stated they are seeing about a 95% SVR 12 rate, very similar to the clinical trials.  

She also stated there were very few relapses if a person was undetected at EOT + 4 and that she was only aware of a couple.  She qualified this stating we were still in the early stages of larger sample results.  The good news is that there are new meds on the way.  Folks that have failed Harvoni will reach their destination, just may take longer.   Take care.



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1b  Int/Riba relapse @ 48 weeks.  Stop tx Peg Int/Riba 12 weeks ill. Relapse S/O 6/23/14 :(   Started Harvoni 11/12/14  EOT 4/28/15.  EOT+4 UND :)  SVR! 8/4/15  :)     Thankful for every morning.
angelseven


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What resistance testing blood test are you doing... i also had the Q80K mutation



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62 year old female      1a, f1-2, had virus 40 years   STARTED HARVONI for 8 weeks 11/19/14, relapsed one month after tx  ended in 1/15.  Fibrosis level was only .5 after fibroscan 12/15. Began treatment with Mavyret on January 20, 2018 for 16 weeks!  Ending May 12.
angelseven


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Sorry for you!!  I also failed 8 weeks of harvoni with 1.6 million viral load.... treatment naive...i wish i had waited to treat.... i had been waiting 20 years for something i thought i could handle... my viral load appeared 4 weeks after eot at 6,000... 3 months after eot 1.5 million... but i am upset as the treatment seemed to interfere with my knee healing and now i have to have knee replacement 8-11, from what i have seen, if someone had an issue during treatment, say lung problem.... sinus stuff... my knee situation it seemed to take a long time to heal and even after treatment had ended problem persists... just saying

I should have waited to see how things panned out for people... when they can do resistance testing for me against whatever the next medication is appropriate for me... then i will retreat....your situation is more serious... i am a 2 fibrosis... but since relapsing my liver is hurting, i just feeling like i am kind of screwed up from the drugs... oh well

I think i have run across about 11 people on facebook and here and there that have relapsed, some were on 12 weeks, several on 24 weeks... and some on 8 weeks

such is life,  good luck to you!!

 



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62 year old female      1a, f1-2, had virus 40 years   STARTED HARVONI for 8 weeks 11/19/14, relapsed one month after tx  ended in 1/15.  Fibrosis level was only .5 after fibroscan 12/15. Began treatment with Mavyret on January 20, 2018 for 16 weeks!  Ending May 12.
canythingbutaverage


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I suspect RAVs are in play, i recently had a blood test which should yield some interesting results. 
I'm hoping they look into some of the other DAAs, since i have the q80k, originally i suspected the issue is with the NS3-4 rather than the NS5A or B.
However with my failure of Harvoni it's more clear it's probably NS-5A. The blood test will tell me what's up.

 

Real world results will differ, the 24 week Harvoni (cirrhosis) clinical trial group was the smallest group of the trials, which is why that initial 100% number was unrealistic. 

 

I'm not a great candidate for trials, but if i can get into one, i'm certain my docs will make it happen. 

I was keeping an eye on the Janssen/Achillion project, but it looks like a rehash of Sovaldi-Olysio. 

and thank you for following, :D



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Miss B


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Rick,
I have been following/admiring your battle for a long time now. I'm sorry & angry that Harvonia failed you. Have you been in touch with the NIH? I know they are doing trials now. You deserve access to the best & strongest treatment available.
Your perseverance is the key to your success. You are now one step closer to success.

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Miss B
56 years old. Genotype 1B, previous treatment with interferon 1994. Started Harvoni 12/8/14. After 2 weeks, VL dropped from over 4 million to 496. At 4 weeks, undetected, but at 8 weeks, <15 mL (detected), at 12 weeks/EOT UND!  
Groupergetter


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Hey Rick, truly sorry to hear of your relapse.  I too relapsed on the Sovaldi/Olysio and just got my 4 week eot labs back from the 24 week Harvoni tx.  Thankfully still und.  As with many others, still waiting for the 12 week SVR labs.  Thanks for sharing.  Your relapse is one of the few Harvoni 24 week tx I've heard of.  Makes me wonder if the real world numbers will differ from the clinical trials?   Most here can somewhat relate to your situation as we've been through it....in some cases many times.  The Harvoni was my 4th try.  Your relapse keeps us grounded in the reality that some won't make it.  You'll get there, hang tough.  Times like this help us all to be thankful for each and every new day.  God bless    



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1b  Int/Riba relapse @ 48 weeks.  Stop tx Peg Int/Riba 12 weeks ill. Relapse S/O 6/23/14 :(   Started Harvoni 11/12/14  EOT 4/28/15.  EOT+4 UND :)  SVR! 8/4/15  :)     Thankful for every morning.
mallani


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Hi Rick,

Sorry to hear your news. Man, you've been through a lot!

Have you been tested for RAV's? It would be vital to know whether you have any Sovaldi RAV's e.g. S282T. If not, Sovaldi can be re-used. You probably have some NS-5A RAV's, but this is not a problem as the newer NS-5A inhibitors are more resistant. It may be worth adding a new antiprotease like Merck's Grazoprevir. This will be a problem for patients, particularly if short treatment times are tried.

Best of luck for the next round mate. You'll get there. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Gracie


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Hi Rick,

I can relate to failing treatment, and I. know what you mean about not wanting to go get your bloodwork done and face the nurses. Since I've found out I'm F4, I don't want to go to my family doctor as it almost feels like I've somehow failed, or didn't try hard enough. It's odd as I know the virus can be a tough one to beat, and not everybody has a successful outcome, at least not yet.

They seem to have unlocked the secrets of the virus lately, and more and more treatments are arriving every day. With how much money they makes it's going to be worthwhile to find ones that work for us hard to cure soldiers. 

I hope the best for you and that this break from the virus for six months gives you a bit or a reprieve from symptoms, and that a customized treatment against any Ravs or whatever it is that prevents SVR is coming your way soon. I feel that it isn't that far away.

Hugs from a fellow warrior! 



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  1. Gracie

1A. Previously treated non responder Rebetron in 2000 And Incevik in 2014 with a breakthrough at week 12. Fibroscan 15.5. VL 6,000,000. Finished 24 weeks harvoni on Dec. 19, 2015. SVR. Latest Fibroscan 8.8.
coolheat


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Sorry to hear that, keep trying and don't give up.  Colheat



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65 YO F, GT 1a1b, ast 14 alt 21, fibrosis 3/4 DX 1968 non a or b, TX 12 wks Harvoni, SOT 6.1.15, 1st bld wk: detected unquantifiable EOT 8.28.15 detected unquantifiable, 3 mo.EOT mid Nov.~SVR 12: ) UNDETECTED
canythingbutaverage


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Thank you all for your kind words, As long as there is a breath within me i will fight on.

I'm keepin my thumb on the pulse of Phase II trials, looking for what could be my next option.
In the mean time, i look for crunchy leaves to step on.

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Tig


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Hey Rick,

Sorry to hear this kind of news. You've tried it all and I commend you for your determination and persistence. You obviously have a Dragon that wants to fight as much as you do. I know you'll prevail because you refuse to give it quarter. Stay strong Brother and never quit trying. You will succeed, believe it...



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Cinnamon Girl


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Hi Rick,

I`m so sorry your Harvoni treatment hasn`t been successful.  It`s rare but it does happen.

This is a good idea for a thread, thanks, and I wish you all the best for your future treatment options.

Take care ... Jill



__________________

Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
canythingbutaverage


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I recently failed the 24 week Harvoni Treatment.
I'm also Cirrhotic, decomp and a previous non-responder.

My docs informed me of one other incident of this happening in my area, so i'm curious to see how common it is.

for reference i failed Sovaldi Olysio last year as well, i zero'd out on both treatments during treatment, and relapsed at end of treatment.

Has anyone else failed Harvoni, or both of these treatments?
If you'd like to give a synopsis of your treatment as i did in the first two lines, it would be helpful for the comparison.

i also made a poll if it's easier.



-- Edited by canythingbutaverage on Tuesday 2nd of June 2015 11:53:26 AM

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